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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MECP2 Antibody Picoband®

SKU : BHA21002235

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Mfr.No.	A00047, A00047-10ug, A00047-Biotin, A00047-Cy3, A00047-Dylight488, A00047-Dylight550, A00047-Dylight594, A00047-FITC, A00047-HRP, A00047-APC, A00047-PE, A00047-iFluor647, A00047-carrier-free
Alternative Names	methyl-CpG binding protein 2
Background	MECP2 (methyl CpG binding protein 2) is a gene that encodes the protein MECP2. It is mapped to Xq28. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alteative splicing results in multiple transcript variants encoding different isoforms.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MECP2 Antibody Picoband® catalog # A00047. Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the co
Host	Rabbit
Immunogen Region	E.coli-derived human MECP2 recombinant protein (Position: K119-R453).
Isotype	Rabbit IgG
Molecular Weight	75 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Methyl-CpG-binding protein 2; MeCp-2 protein; MeCp2; MECP2
Tissue Specificity	Present in all adult somatic tissues tested.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P51608
Gene Id	4204
Gene Name	MECP2
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br> Immunocytochemistry/Immunofluorescence, 2ug/ml<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY(October 1999). "Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2". Nat. Genet. 23 (2): 1858.<br /><br />2. Chahrour M, et al. (2008). "MECP2, a key contributor to neurological disease, activates and represses transcription". Science. 320 (5880): 12249.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002235-1	A00047	-	100 ug	$370		Add to Cart
BHA21002235-2	A00047-10ug	Sample	10 ug	$99		Add to Cart
BHA21002235-3	A00047-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002235-4	A00047-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002235-5	A00047-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002235-6	A00047-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002235-7	A00047-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002235-8	A00047-FITC	FITC	100 ug	$570		Add to Cart
BHA21002235-9	A00047-HRP	HRP	100 ug	$570		Add to Cart
BHA21002235-10	A00047-APC	APC	100 ug	$670		Add to Cart
BHA21002235-11	A00047-PE	PE	100 ug	$670		Add to Cart
BHA21002235-12	A00047-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002235-13	A00047-carrier-free	carrier-free	100 ug	$370		Add to Cart

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