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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MDH2 Antibody Picoband®

SKU : BHA21003594

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Mfr.No.	A04803-2, A04803-2-10ug, A04803-2-Biotin, A04803-2-Cy3, A04803-2-Dylight488, A04803-2-Dylight550, A04803-2-Dylight594, A04803-2-FITC, A04803-2-HRP, A04803-2-APC, A04803-2-PE, A04803-2-iFluor647, A04803-2-carrier-free
Alternative Names	mediator complex subunit 14
Background	Malate dehydrogenase, mitochondrial also known as malate dehydrogenase 2 is an enzyme that in humans is encoded by the MDH2 gene. Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MDH2 Antibody Picoband® catalog # A04803-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymera
Host	Rabbit
Immunogen Region	E.coli-derived human MDH2 recombinant protein (Position: A9-L223).
Isotype	Rabbit IgG
Molecular Weight	36 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Mediator of RNA polymerase II transcription subunit 14; Activator-recruited cofactor 150 kDa component; ARC150; Cofactor required for Sp1 transcriptional activation subunit 2; CRSP complex subunit 2; Mediator complex subunit 14; RGR1 homolog; hRGR1; Thyroid hormone receptor-associated protein complex 170 kDa component; Trap170; Transcriptional coactivator CRSP150; Vitamin D3 receptor-interacting protein complex 150 kDa component; DRIP150; MED14; ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170;
Tissue Specificity	Ubiquitous.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P40926
Gene Id	4191
Gene Name	MDH2
Subcellular Location	Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.1-0.25 ug/ml, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 1-2 ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Ait-El-Mkadem, S., Dayem-Quere, M., Gusic, M., Chaussenot, A., Bannwarth, S., Francois, B., Genin, E. C., Fragaki, K., Volker-Touw, C. L. M., Vasnier, C., Serre, V., van Gassen, K. L. I., and 24 others. Mutations in MDH2, encoding a Krebs cycle enzyme, cause early-onset severe encephalopathy. Am. J. Hum. Genet. 100: 151-159, 2017. 2. Benn, P., Che, C. J., Bruns, G., Craig, I. W., Croce, C. M. Assignment of the genes for human beta-glucuronidase and mitochondrial malate dehydrogenase to the region pter-q22 of chromosome 7. Cytogenet. Cell Genet. 19: 273-280, 1977. 3. Blake, N. M. Malate dehydrogenase types in the Asian-Pacific area, and a description of new phenotypes. Hum. Genet. 43: 69-80, 1978.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003594-1	A04803-2	-	100 ug	$370		Add to Cart
BHA21003594-2	A04803-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003594-3	A04803-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003594-4	A04803-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003594-5	A04803-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003594-6	A04803-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003594-7	A04803-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003594-8	A04803-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003594-9	A04803-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003594-10	A04803-2-APC	APC	100 ug	$670		Add to Cart
BHA21003594-11	A04803-2-PE	PE	100 ug	$670		Add to Cart
BHA21003594-12	A04803-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003594-13	A04803-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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