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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MCM7 Antibody Picoband®

SKU : BHA21007062

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Mfr.No.	PA1792, PA1792-10ug, PA1792-Biotin, PA1792-Cy3, PA1792-Dylight488, PA1792-Dylight550, PA1792-Dylight594, PA1792-FITC, PA1792-HRP, PA1792-APC, PA1792-PE, PA1792-iFluor647, PA1792-carrier-free
Alternative Names	DNA replication licensing factor MCM7
Background	MCM7 (Minichromosome Maintenance, s. Cerevisiae, homolog of, 7), also called CDC47, FORMERLY, is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The MCM7 gene is mapped on 7q22.1. MCM7 plays a pivotal role in the G1/S phase transition, orchestrating the correct assembly of replication forks on chromosomal DNA and ensuring that all the genome is replicated once and not more than once at each cell cycle. The MCM7 gene contains 15 exons. The miRNAs MIR106B, MIR93, and MIR25 are clustered in a 5-prime to 3-prime orientation within intron 13. Petrocca et al. (2008) found that MCM7 and the precursors of microRNAs (miRNAs) MIR106B, MIR93, and MIR25, all of which arise from intron 13 of the MCM7 gene, were overexpressed with almost perfect correlation in 5 of 10 human gastric tumors.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MCM7 Antibody catalog # PA1792. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed throu
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human MCM7.
Isotype	Rabbit IgG
Molecular Weight	80 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	DNA replication licensing factor MCM7;3.6.4.12;CDC47 homolog;P1.1-MCM3;MCM7;CDC47, MCM2;
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P33993
Gene Name	MCM7
Sequence	Belongs to the MCM family.
Subcellular Location	Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human

Reference	1. Groth, A., Corpet, A., Cook, A. J. L., Roche, D., Bartek, J., Lukas, J., Almouzni, G. Regulation of replication fork progression through histone supply and demand. Science 318: 1928-1931, 2007. <br /><br />2. Nakatsuru, S., Sudo, K., Nakamura, Y. Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication.Cytogenet. Cell Genet. 68: 226-230, 1995.<br /><br />3. Petrocca, F., Visone, R., Onelli, M. R., Shah, M. H., Nicoloso, M. S., de Martino, I., Iliopoulos, D., Pilozzi, E., Liu, C.-G., Negrini, M., Cavazzini, L., Volinia, S., Alder, H., Ruco, L. P., Baldassarre, G., Croce, C. M., Vecchione, A. E2F1-regulated microRNAs impair TGF-beta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 13: 272-286, 2008.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007062-1	PA1792	-	100 ug	$370		Add to Cart
BHA21007062-2	PA1792-10ug	Sample	10 ug	$99		Add to Cart
BHA21007062-3	PA1792-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007062-4	PA1792-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007062-5	PA1792-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007062-6	PA1792-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007062-7	PA1792-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007062-8	PA1792-FITC	FITC	100 ug	$570		Add to Cart
BHA21007062-9	PA1792-HRP	HRP	100 ug	$570		Add to Cart
BHA21007062-10	PA1792-APC	APC	100 ug	$670		Add to Cart
BHA21007062-11	PA1792-PE	PE	100 ug	$670		Add to Cart
BHA21007062-12	PA1792-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007062-13	PA1792-carrier-free	carrier-free	100 ug	$370		Add to Cart

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