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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Matrix metalloproteinase-14 MMP14 Antibody Picoband®

SKU : BHA21007348

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Mfr.No.	PA2147, PA2147-10ug, PA2147-Biotin, PA2147-Cy3, PA2147-Dylight488, PA2147-Dylight550, PA2147-Dylight594, PA2147-FITC, PA2147-HRP, PA2147-APC, PA2147-PE, PA2147-iFluor647, PA2147-carrier-free
Alternative Names	Matrix metalloproteinase-14
Background	Matrix metalloproteinase-14, also called MT-MMP 1, is an enzyme that in humans is encoded by the MMP14 gene. The protein encoded by this gene is a member of the membrane-type MMP subfamily. This gene is mapped to 14q11.2. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene may be involved in actin cytoskeleton reorganization by cleaving PTK7. It acts as a positive regulator of cell growth and migration via activation of MMP15.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Matrix metalloproteinase-14 MMP14 Antibody catalog # PA2147. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell g
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human MMP14, different from the related mouse and rat sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Matrix metalloproteinase-14;MMP-14;3.4.24.80;MMP-X1;Membrane-type matrix metalloproteinase 1;MT-MMP 1;MTMMP1;Membrane-type-1 matrix metalloproteinase;MT1-MMP;MT1MMP;MMP14;
Tissue Specificity	Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P50281
Gene Name	MMP14
Sequence	Belongs to the peptidase M10A family.
Subcellular Location	Membrane ; Single-pass type I membrane protein . Melanosome. Cytoplasm. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Chun, T.-H., Hotary, K. B., Sabeh, F., Saltiel, A. R., Allen, E. D., Weiss, S. J. A pericellular collagenase s the 3-dimensional development of white adipose tissue. Cell 125: 577-591, 2006.<br /><br />2. Oh, J., Takahashi, R., Adachi, E., Kondo, S., Kuratomi, S., Noma, A., Alexander, D. B., Motoda, H., Okada, A., Seiki, M., Itoh, T., Itohara, S., Takahashi, C., Noda, M. Mutations in two matrix metalloproteinase genes, MMP-2, and MT1-MMP, are synthetic lethal in mice. Oncogene 23: 5041-5048, 2004.<br /><br />3. Ueda, M., Yamashita, Y., Takehara, M., Terai, Y., Kumagai, K., Ueki, K., Kanda, K., Yamaguchi, H., Akise, D., Hung, Y.-C., Ueki, M. Survivin gene expression in endometriosis. J. Clin. Endocr. Metab. 87: 3452-3459, 2002. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007348-1	PA2147	-	100 ug	$370		Add to Cart
BHA21007348-2	PA2147-10ug	Sample	10 ug	$99		Add to Cart
BHA21007348-3	PA2147-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007348-4	PA2147-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007348-5	PA2147-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007348-6	PA2147-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007348-7	PA2147-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007348-8	PA2147-FITC	FITC	100 ug	$570		Add to Cart
BHA21007348-9	PA2147-HRP	HRP	100 ug	$570		Add to Cart
BHA21007348-10	PA2147-APC	APC	100 ug	$670		Add to Cart
BHA21007348-11	PA2147-PE	PE	100 ug	$670		Add to Cart
BHA21007348-12	PA2147-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007348-13	PA2147-carrier-free	carrier-free	100 ug	$370		Add to Cart

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