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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MAPK8/9 Antibody Picoband®

SKU : BHA21006772

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Mfr.No.	PA1407, PA1407-10ug, PA1407-Biotin, PA1407-Cy3, PA1407-Dylight488, PA1407-Dylight550, PA1407-Dylight594, PA1407-FITC, PA1407-HRP, PA1407-APC, PA1407-PE, PA1407-iFluor647, PA1407-carrier-free
Alternative Names	Mitogen-activated protein kinase 8/9
Background	Mitogen-activated protein kinase 8 is an enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this gene is a member of the MAP kinase family. The Inteational Radiation Hybrid Mapping Consortium mapped the MAPK8 gene to chromosome 10. The single long open reading frame encodes a putative protein kinase with a predicted mass of 44.2 kD. This kinase play a key role in T cell proliferation, apoptosis and differentiation. The protein encoded by MAPK9 gene is also a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alteatively spliced transcript variants encoding distinct isoforms have been reported.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MAPK8/9 Antibody catalog # PA1407. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human MAPK8/9, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	65 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Mitogen-activated protein kinase 8;MAP kinase 8;MAPK 8;2.7.11.24;JNK-46;Stress-activated protein kinase 1c;SAPK1c;Stress-activated protein kinase JNK1;c-Jun N-terminal kinase 1;MAPK8;JNK1, PRKM8, SAPK1, SAPK1C; JNK2, MAPK9
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P45983, P45984
Gene Name	MAPK8
Sequence	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Subcellular Location	Cytoplasm . Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat -<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ (Apr 1994). "JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain". Cell 76 (6): 102537. doi:10.1016/0092-8674(94)90380-8. PMID 8137421. <br /><br />2. Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Derijard B, Davis RJ (Jul 1996). "Selective interaction of JNK protein kinase isoforms with transcription factors". EMBO J 15 (11): 276070. PMC 450211. PMID 8654373.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006772-1	PA1407	-	100 ug	$370		Add to Cart
BHA21006772-2	PA1407-10ug	Sample	10 ug	$99		Add to Cart
BHA21006772-3	PA1407-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006772-4	PA1407-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006772-5	PA1407-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006772-6	PA1407-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006772-7	PA1407-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006772-8	PA1407-FITC	FITC	100 ug	$570		Add to Cart
BHA21006772-9	PA1407-HRP	HRP	100 ug	$570		Add to Cart
BHA21006772-10	PA1407-APC	APC	100 ug	$670		Add to Cart
BHA21006772-11	PA1407-PE	PE	100 ug	$670		Add to Cart
BHA21006772-12	PA1407-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006772-13	PA1407-carrier-free	carrier-free	100 ug	$370		Add to Cart

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