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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MAPK1/3 Antibody Picoband®

SKU : BHA21006636

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Mfr.No.	PA1049, PA1049-10ug, PA1049-Biotin, PA1049-Cy3, PA1049-Dylight488, PA1049-Dylight550, PA1049-Dylight594, PA1049-FITC, PA1049-HRP, PA1049-APC, PA1049-PE, PA1049-iFluor647, PA1049-carrier-free
Alternative Names	Mitogen-activated protein kinase 1
Background	MAPK1 (ERK2) shares high homology with MAPK3 (ERK1). MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Mitogen-activated protein (MAP) kinases (also known as Erks) have been established to function as important mediators of signal transduction by growth factor receptors. ERK1/ERK2-dependent activation of endogenous ribosomal transcription, while inactivation of ERK1/ERK2 causes an equally immediate reversion to the basal transcription level. ERK1/ERK2 was found to phosphorylate the architectural transcription factor UBF at amino acids 117 and 201 within HMG boxes 1 and 2, preventing their interaction with DNA. Mutation of these sites inhibited transcription activation and abrogated the transcriptional response to ERK1/ERK2.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-MAPK1/3 Antibody catalog # PA1049. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initia
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human MAPK1/3, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Mitogen-activated protein kinase 1;MAP kinase 1;MAPK 1;2.7.11.24;ERT1;Extracellular signal-regulated kinase 2;ERK-2;MAP kinase isoform p42;p42-MAPK;Mitogen-activated protein kinase 2;MAP kinase 2;MAPK 2;MAPK1;ERK2, PRKM1, PRKM2;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P28482
Gene Name	MAPK1
Sequence	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Subcellular Location	Cytoplasm, cytoskeleton, spindle . Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Associated with the spindle during prometaphase and metaphase (By similarity). PEA15- binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Bhalla, U. S.; Ram, P. T.; Iyengar, R. : MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297: 1018-1023, 2002. <br /><br />2. Li, L.; Wysk, M.; Gonzalez, F. A.; Davis, R. J. : Genomic loci of human mitogen-activated protein kinases. Oncogene 9: 647-649, 1994.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006636-1	PA1049	-	100 ug	$370		Add to Cart
BHA21006636-2	PA1049-10ug	Sample	10 ug	$99		Add to Cart
BHA21006636-3	PA1049-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006636-4	PA1049-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006636-5	PA1049-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006636-6	PA1049-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006636-7	PA1049-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006636-8	PA1049-FITC	FITC	100 ug	$570		Add to Cart
BHA21006636-9	PA1049-HRP	HRP	100 ug	$570		Add to Cart
BHA21006636-10	PA1049-APC	APC	100 ug	$670		Add to Cart
BHA21006636-11	PA1049-PE	PE	100 ug	$670		Add to Cart
BHA21006636-12	PA1049-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006636-13	PA1049-carrier-free	carrier-free	100 ug	$370		Add to Cart

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