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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MANSC1 Antibody Picoband®

SKU : BHA21005617

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Mfr.No.	A15720-2, A15720-2-10ug, A15720-2-Biotin, A15720-2-Cy3, A15720-2-Dylight488, A15720-2-Dylight550, A15720-2-Dylight594, A15720-2-FITC, A15720-2-HRP, A15720-2-APC, A15720-2-PE, A15720-2-iFluor647, A15720-2-carrier-free
Alternative Names	kelch repeat and BTB domain containing 2
Background	MANSC1 (MANSC domain-containing protein 1), also known as LOH12CR3 (Loss of heterozygosity 12 chromosomal region 3 protein), is a 414 amino acid single-pass membrane protein. Expressed throughout the body, MANSC1 contains one MANSC domain and is encoded by a gene that is located on chromosome 12. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MANSC1 Antibody Picoband® catalog # A15720-2. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completio
Host	Rabbit
Immunogen Region	E.coli-derived human MANSC1 recombinant protein (Position: L21-N337).
Isotype	Rabbit IgG
Molecular Weight	62 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489
Tissue Specificity	Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9H8J5
Gene Id	54682
Gene Name	MANSC1
Subcellular Location	Cul3-RING ubiquitin ligase complex.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Clark, H. F. , Guey, A. L. , Abaya, E. , Baker, K. , Baldwin, D. , & Brush, J. , et al. (2003). The secreted protein discovery initiative (spdi), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Research, 13(10), 2265-2276.<br /><br />2. Ezh2 depletion potentiates myc degradation inhibiting neuroblastoma and small cell carcinoma tumor formation. Nature Communications.<br /><br />3. Luck, K. , Kim, D. K. , Lamboue, L. , Spirohn, K. , & Calderwood, M. A. . (2020). A reference map of the human binary protein interactome. Nature, 580(D1).

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005617-1	A15720-2	-	100 ug	$370		Add to Cart
BHA21005617-2	A15720-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21005617-3	A15720-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005617-4	A15720-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005617-5	A15720-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005617-6	A15720-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005617-7	A15720-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005617-8	A15720-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21005617-9	A15720-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21005617-10	A15720-2-APC	APC	100 ug	$670		Add to Cart
BHA21005617-11	A15720-2-PE	PE	100 ug	$670		Add to Cart
BHA21005617-12	A15720-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005617-13	A15720-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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