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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Mannose 6 Phosphate Receptor (Cation independent)/IGF2R Antibody Picoband®

SKU : BHA21001646

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Mfr.No.	A00951, A00951-10ug, A00951-Biotin, A00951-Cy3, A00951-Dylight488, A00951-Dylight550, A00951-Dylight594, A00951-FITC, A00951-HRP, A00951-APC, A00951-PE, A00951-iFluor647, A00951-carrier-free
Alternative Names	insulin-like growth factor 2 receptor
Background	Insulin-like growth factor 2 receptor, also called IGF2R or I-MPR is a protein that in humans is encoded by the IGF2R gene. This gene is mapped to 6q25.3. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the mateal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the mateal allele.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Mannose 6 Phosphate Receptor (Cation independent)/IGF2R Antibody Picoband® catalog # A00951. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting recepto
Host	Rabbit
Immunogen Region	E. coli-derived human IGF2R recombinant protein (Position: F424-R529).
Isotype	Rabbit IgG
Molecular Weight	274 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; M6PR; 300 kDa mannose 6-phosphate receptor; MPR 300; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; IGF-II receptor; M6P/IGF2 receptor; M6P/IGF2R; CD222; IGF2R; MPRI
Tissue Specificity	Liver.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P11717
Gene Id	3482
Gene Name	IGF2R
Subcellular Location	Lysosome membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IF, IHC, ICC, WB, Flow Cytometry
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml<br> Immunocytochemistry/Immunofluorescence, 5ug/ml<br> Flow Cytometry(Fixed), 1-3ug/1x10<sup>6</sup> cells<br> ELISA, 0.1-0.5ug/ml<br>

Reference	1. Killian, J. K., Oka, Y., Jang, H.-S., Fu, X., Waterland, R. A., Sohda, T., Sakaguchi, S., Jirtle, R. L. Mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) variants in American and Japanese populations. Hum. Mutat. 18: 25-31, 2001.<br /><br />2. Latos, P. A., Pauler, F. M., Koeer, M. V., Senergin, H. B., Hudson, Q. J., Stocsits, R. R., Allhoff, W., Stricker, S. H., Klement, R. M., Warczok, K. E., Aumayr, K., Pasierbek, P., Barlow, D. P. Ai transcriptional overlap, but not its IncRNA products, induces imprinted Igf2r silencing. Science 338: 1469-1472, 2012.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001646-1	A00951	100 ug	-	$370		Add to Cart
BHA21001646-2	A00951-10ug	10 ug	Sample	$99		Add to Cart
BHA21001646-3	A00951-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001646-4	A00951-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001646-5	A00951-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001646-6	A00951-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001646-7	A00951-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001646-8	A00951-FITC	100 ug	FITC	$570		Add to Cart
BHA21001646-9	A00951-HRP	100 ug	HRP	$570		Add to Cart
BHA21001646-10	A00951-APC	100 ug	APC	$670		Add to Cart
BHA21001646-11	A00951-PE	100 ug	PE	$670		Add to Cart
BHA21001646-12	A00951-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001646-13	A00951-carrier-free	100 ug	carrier-free	$370		Add to Cart

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