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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Mannose 6 Phosphate Receptor (Cation independent)/IGF2R Antibody Picoband®

SKU : BHA21007379

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Mfr.No.	PA2182, PA2182-10ug, PA2182-Biotin, PA2182-Cy3, PA2182-Dylight488, PA2182-Dylight550, PA2182-Dylight594, PA2182-FITC, PA2182-HRP, PA2182-APC, PA2182-PE, PA2182-iFluor647, PA2182-carrier-free
Alternative Names	Cation-independent mannose-6-phosphate receptor
Background	Insulin-like growth factor 2 receptor, also called IGF2R or I-MPR is a protein that in humans is encoded by the IGF2R gene. This gene is mapped to 6q25.3. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the mateal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the mateal allele.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Mannose 6 Phosphate Receptor (Cation independent)/IGF2R Antibody catalog # PA2182. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting recepto
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Mannose 6 Phosphate Receptor(Cation independent), different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	274 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cation-independent mannose-6-phosphate receptor;CI Man-6-P receptor;CI-MPR;M6PR;300 kDa mannose 6-phosphate receptor;MPR 300;Insulin-like growth factor 2 receptor;Insulin-like growth factor II receptor;IGF-II receptor;M6P/IGF2 receptor;M6P/IGF2R;CD222;IGF2R;MPRI;
Tissue Specificity	Highly expressed in liver, kidney, lung and skin. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P11717
Gene Name	IGF2R
Sequence	Belongs to the MRL1/IGF2R family.
Subcellular Location	Lysosome membrane ; Single-pass type I membrane protein . Colocalized with DPP4 in intealized cytoplasmic vesicles adjacent to the cell surface.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, Flow Cytometry
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Flow Cytometry(Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Killian, J. K., Oka, Y., Jang, H.-S., Fu, X., Waterland, R. A., Sohda, T., Sakaguchi, S., Jirtle, R. L. Mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) variants in American and Japanese populations. Hum. Mutat. 18: 25-31, 2001.<br /><br />2. Latos, P. A., Pauler, F. M., Koeer, M. V., Senergin, H. B., Hudson, Q. J., Stocsits, R. R., Allhoff, W., Stricker, S. H., Klement, R. M., Warczok, K. E., Aumayr, K., Pasierbek, P., Barlow, D. P. Ai transcriptional overlap, but not its IncRNA products, induces imprinted Igf2r silencing. Science 338: 1469-1472, 2012. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007379-1	PA2182	-	100 ug	$370		Add to Cart
BHA21007379-2	PA2182-10ug	Sample	10 ug	$99		Add to Cart
BHA21007379-3	PA2182-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007379-4	PA2182-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007379-5	PA2182-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007379-6	PA2182-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007379-7	PA2182-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007379-8	PA2182-FITC	FITC	100 ug	$570		Add to Cart
BHA21007379-9	PA2182-HRP	HRP	100 ug	$570		Add to Cart
BHA21007379-10	PA2182-APC	APC	100 ug	$670		Add to Cart
BHA21007379-11	PA2182-PE	PE	100 ug	$670		Add to Cart
BHA21007379-12	PA2182-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007379-13	PA2182-carrier-free	carrier-free	100 ug	$370		Add to Cart

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