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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MADH7/SMAD7 Antibody Picoband®

SKU : BHA21004363

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Mfr.No.	A00784-2, A00784-2-10ug, A00784-2-Biotin, A00784-2-Cy3, A00784-2-Dylight488, A00784-2-Dylight550, A00784-2-Dylight594, A00784-2-FITC, A00784-2-HRP, A00784-2-APC, A00784-2-PE, A00784-2-iFluor647, A00784-2-carrier-free
Alternative Names	potassium voltage-gated channel, subfamily H (eag-related), member 2
Background	Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MADH7/SMAD7 Antibody Picoband® catalog # A00784-2. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isofo
Host	Rabbit
Immunogen Region	E.coli-derived human MADH7/SMAD7 recombinant protein (Position: A88-R135).
Isotype	Rabbit IgG
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Potassium voltage-gated channel subfamily H member 2; Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; Herg1; Voltage-gated potassium channel subunit Kv11.1; KCNH2; ERG; ERG1; HERG
Tissue Specificity	Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	O15105
Gene Id	4092
Gene Name	SMAD7
Subcellular Location	Cell membrane. Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Mouse, Rat<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Broderick, P., Carvajal-Carmona, L., Pittman, A. M., Webb, E., Howarth, K., Rowan, A., Lubbe, S., Spain, S., Sullivan, K., Fielding, S., Jaeger, E., Vijayakrishnan, J., and 20 others. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nature Genet. 39: 1315-1317, 2007. <br /><br />2. Dong, C., Zhu, S., Wang, T., Yoon, W., Li, Z., Alvarez, R. J., ten Dijke, P., White, B., Wigley, F. M., Goldschmidt-Clermont, P. J. Deficient Smad7 expression: a putative molecular defect in scleroderma. Proc. Nat. Acad. Sci. 99: 3908-3913, 2002. Note: Retraction: Proc. Nat. Acad. Sci. 113: E2208, 2016. <br /><br />3. Fukasawa, H., Yamamoto, T., Togawa, A., Ohashi, N., Fujigaki, Y., Oda, T., Uchida, C., Kitagawa, K., Hattori, T., Suzuki, S., Kitagawa, M., Hishida, A. Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proc. Nat. Acad. Sci. 101: 8687-8692, 2004.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004363-1	A00784-2	-	100 ug	$370		Add to Cart
BHA21004363-2	A00784-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004363-3	A00784-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004363-4	A00784-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004363-5	A00784-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004363-6	A00784-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004363-7	A00784-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004363-8	A00784-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004363-9	A00784-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004363-10	A00784-2-APC	APC	100 ug	$670		Add to Cart
BHA21004363-11	A00784-2-PE	PE	100 ug	$670		Add to Cart
BHA21004363-12	A00784-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004363-13	A00784-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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