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Home / Primary Antibodies / Polyclonal Antibodies

Anti-MADCAM1 Antibody Picoband®

SKU : BHA21003959

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Mfr.No.	A04227-3, A04227-3-10ug, A04227-3-Biotin, A04227-3-Cy3, A04227-3-Dylight488, A04227-3-Dylight550, A04227-3-Dylight594, A04227-3-FITC, A04227-3-HRP, A04227-3-APC, A04227-3-PE, A04227-3-iFluor647, A04227-3-carrier-free
Alternative Names	mucosal vascular addressin cell adhesion molecule 1
Background	MADCAM1 (Mucosal Vascular Addressin Cell Adhesion Molecule 1), also known as MACAM1, is a protein that in humans is encoded by the MADCAM1 gene. By PCR-based analysis of somatic cell hybrids, this gene is mapped to chromosome 19. The protein encoded by this gene is an endothelil cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-MADCAM1 Antibody Picoband® catalog # A04227-3. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cell adhesion leukocyte receptor expressed by mucosal venules, helps to lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the pa
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human MADCAM1, which shares 46.2% amino acid (aa) sequence identity with mouse MADCAM1.
Isotype	Rabbit IgG
Molecular Weight	50 kDa
Reactivity	Human, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Mucosal addressin cell adhesion molecule 1; MAdCAM-1; hMAdCAM-1; MADCAM1
Tissue Specificity	Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q13477
Gene Id	8174
Gene Name	MADCAM1
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB
Description	Weste blot, 0.25-0.5 ug/ml, Human, Rat

Reference	1. Briskin, M. J., McEvoy, L. M., Butcher, E. C. MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. Nature 363: 461-464, 1993. 2. Entrez Gene: mucosal vascular addressin cell adhesion molecule 1. 3. Leung, E., Berg, R. W., Langley, R., Greene, J., Raymond, L. A., Augustus, M., Ni, J., Carter, K. C., Spurr, N., Choo, K. H. A., Krissansen, G. W. Genomic organization, chromosomal mapping, and analysis of the 5-prime promoter region of the human MAdCAM-1 gene. Immunogenetics 46: 111-119, 1997.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003959-1	A04227-3	-	100 ug	$370		Add to Cart
BHA21003959-2	A04227-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21003959-3	A04227-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003959-4	A04227-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003959-5	A04227-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003959-6	A04227-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003959-7	A04227-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003959-8	A04227-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21003959-9	A04227-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21003959-10	A04227-3-APC	APC	100 ug	$670		Add to Cart
BHA21003959-11	A04227-3-PE	PE	100 ug	$670		Add to Cart
BHA21003959-12	A04227-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003959-13	A04227-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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