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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Macrosialin CD68 Antibody Picoband®

SKU : BHA21006858

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Mfr.No.	PA1518, PA1518-10ug, PA1518-Biotin, PA1518-Cy3, PA1518-Dylight488, PA1518-Dylight550, PA1518-Dylight594, PA1518-FITC, PA1518-HRP, PA1518-APC, PA1518-PE, PA1518-iFluor647, PA1518-carrier-free
Alternative Names	Macrosialin
Background	CD68 is a heavily glycosylated glycoprotein that is highly expressed in macrophages and other mononuclear phagocytes. Macrosialin, if not glycosylated, has the main sequence that consists of 354 amino acids with an expected molecular weight of 37.4 kD. CD68, which can be located in the cytoplasmic granules of a variety of blood cells and myocytes, can be detected via immunohistochemistry. It's particularly effective as a marker for monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts, all of which belong to the macrophage lineage. CD68 is expressed in tissue macrophages and to a lesser extent in dendritic cells.CD68 is involved in tissue macrophage phagocytic activities, as well as intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. It works by binding to tissue and organ-specific lectins or selectins, enabling macrophage subsets to be ed to specific locations. Macrophages may be able to crawl over selectin-bearing substrates or other cells if CD68 is rapidly recirculated from endosomes and lysosomes to the plasma membrane.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	<p class="text-grey mb-2"><strong>Superstar antibody: Boster s anti mouse CD68 antibody (PA1518) is among its top 10 bestselling antibodies, and one of the most cited mouse/rat CD68 antibodies on the market. Because of this antibody s high demand, we have subsequently developed <a href="/anti-cd68-rabbit-monoclonal-antibody-m00602-1-boster.html" target="_blank">a rabbit monoclonal anti CD68 antibody (M00602-1)</a> targetting a similar epitope.</p> <p class="text-grey mb-2"><strong>High specificity: PA1518 reacts with murine macrosialin/CD68, and has been validated with Weste blotting and confirmed its stellar specificity. CD68 is a highly glycosylated protein, and its expected weste blot molecular weight is between 80kDa to 110kDa, depending on glycosylation level. PA1518 s observed MW in WB is near 90-100kDa. Testing on negative control tissues showed no significant bands (images available on request) or staining. See more info in the positive and negative control design section. Based on immunogen sequence homology, this antibody is not expected to cross react with other proteins from the LAMP family, which complies with QC testing observations. </p> <p class="text-grey mb-2"><strong>Great for CD68 IHC: This antibody produces clean and specific immunobiological stains in both mouse and rat tissues. Our QC team has validated it on spleen and liver tissues of both mice and rats. Click product images for more details on experiment conditions.</p> <p class="text-grey mb-2"><strong>More about CD68: CD68 is a cell surface marker often used to identify macrophages and other cell types in the monocyte lineage. It is a transmembrane protein that binds to electins and selectins and plays a role in macrophage homing movement. Check out the <a href="/bosterbio-gene-info-cards/CD68" target="_blank">CD68 </a>biomarker page for more information on CD68 and view all CD68 antibodies, ELISA kits and proteins. </p> The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophag
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of mouse CD68, different from the related rat sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	90-100 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Macrosialin;CD68;Cd68;
Tissue Specificity	Expressed in tissue macrophages and to a lesser extent in dendritic cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P31996
Gene Name	CD68
Sequence	Belongs to the LAMP family.
Subcellular Location	Isoform Long: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, WB, Flow Cytometry
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Mouse, Rat, By Heat<br> Immunofluorescence, 5ug/ml, Mouse<br> Flow Cytometry(Fixed), 1-3 ug/1x10<sup>6</sup> cells, Mouse<br>

Reference	1. Holness, C. L., Simmons, D. L.Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins.Blood 81: 1607-1613, 1993.<br /><br />2. Jones, E., Quinn, C. M., See, C. G., Montgomery, D. S., Ford, M. J., Kolble, K., Gordon, S., Greaves, D. R.The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes map to chromosome 17p13.Genomics 53: 248-250, 1998.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006858-1	PA1518	-	100 ug	$370		Add to Cart
BHA21006858-2	PA1518-10ug	Sample	10 ug	$99		Add to Cart
BHA21006858-3	PA1518-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006858-4	PA1518-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006858-5	PA1518-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006858-6	PA1518-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006858-7	PA1518-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006858-8	PA1518-FITC	FITC	100 ug	$570		Add to Cart
BHA21006858-9	PA1518-HRP	HRP	100 ug	$570		Add to Cart
BHA21006858-10	PA1518-APC	APC	100 ug	$670		Add to Cart
BHA21006858-11	PA1518-PE	PE	100 ug	$670		Add to Cart
BHA21006858-12	PA1518-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006858-13	PA1518-carrier-free	carrier-free	100 ug	$370		Add to Cart

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