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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Macrophage metalloelastase MMP12 Antibody Picoband®

SKU : BHA21007347

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Mfr.No.	PA2146, PA2146-10ug, PA2146-Biotin, PA2146-Cy3, PA2146-Dylight488, PA2146-Dylight550, PA2146-Dylight594, PA2146-FITC, PA2146-HRP, PA2146-APC, PA2146-PE, PA2146-iFluor647, PA2146-carrier-free
Alternative Names	Macrophage metalloelastase
Background	Matrix metalloproteinase-12 (MMP12), also known as MME or ME, is an enzyme that in humans is encoded by the MMP12 gene. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.2. It is though that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. This gene may involved in tissue injury and remodeling.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Macrophage metalloelastase MMP12 Antibody catalog # PA2146. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydr
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human MMP12.
Isotype	Rabbit IgG
Molecular Weight	49 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Macrophage metalloelastase;MME;3.4.24.65;Macrophage elastase;ME;hME;Matrix metalloproteinase-12;MMP-12;MMP12;HME;
Tissue Specificity	Found in alveolar macrophages but not in peripheral blood monocytes.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P39900
Gene Name	MMP12
Sequence	Belongs to the peptidase M10A family.
Subcellular Location	Secreted, extracellular space, extracellular matrix .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Houghton, A. M., Hartzell, W. O., Robbins, C. S., Gomis-Ruth, F. X., Shapiro, S. D.Macrophage elastase kills bacteria within murine macrophages. Nature 460: 637-641, 2009. <br /><br />2. Joos, L., He, J.-Q., Shepherdson, M. B., Connett, J. E., Anthonisen, N. R., Pare, P. D., Sandford, A. J. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Hum. Molec. Genet. 11: 569-576, 2002. Note: Erratum: Hum. Molec. Genet. 12: 803-804, 2003.<br /><br />3. Wu, L., Tanimoto, A., Murata, Y., Sasaguri, T., Fan, J., Sasaguri, Y., Watanabe, T. Matrix metalloproteinase-12 gene expression in human vascular smooth muscle cells.Genes Cells 8: 225-234, 2003.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007347-1	PA2146	-	100 ug	$370		Add to Cart
BHA21007347-2	PA2146-10ug	Sample	10 ug	$99		Add to Cart
BHA21007347-3	PA2146-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007347-4	PA2146-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007347-5	PA2146-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007347-6	PA2146-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007347-7	PA2146-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007347-8	PA2146-FITC	FITC	100 ug	$570		Add to Cart
BHA21007347-9	PA2146-HRP	HRP	100 ug	$570		Add to Cart
BHA21007347-10	PA2146-APC	APC	100 ug	$670		Add to Cart
BHA21007347-11	PA2146-PE	PE	100 ug	$670		Add to Cart
BHA21007347-12	PA2146-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007347-13	PA2146-carrier-free	carrier-free	100 ug	$370		Add to Cart

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