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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Macrophage Inflammatory Protein 1 beta/CCL4 Antibody Picoband®

SKU : BHA21007520

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Mfr.No.	PB9064, PB9064-10ug, PB9064-Biotin, PB9064-Cy3, PB9064-Dylight488, PB9064-Dylight550, PB9064-Dylight594, PB9064-FITC, PB9064-HRP, PB9064-APC, PB9064-PE, PB9064-iFluor647, PB9064-carrier-free
Alternative Names	C-C motif chemokine 4
Background	Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in human is encoded by the CCL4 gene. By analysis of somatic cell hybrids and by in situ hybridization, the CCL4 gene was assigned to 17q21-q23. It is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Performing-low memory CD8+ T cells that normally synthesize CCL4. Based on functional analysis of CCL4, one or more additional beta chemokine receptors that transduce CCL4 signals must also exist. MIP-1alpha and CCL4 have been shown to lack affinity for the erythrocyte surface chemokine receptor/Duffy antigen that binds many alpha as well as beta chemokines (11, 14).
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Macrophage Inflammatory Protein 1 beta/CCL4 Antibody Picoband® catalog # PB9064. Tested in IHC, WB applications. This antibody reacts with Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Monokine with inflammatory and chemokinetic properties.
Host	Rabbit
Immunogen Region	E.coli-derived rat CCL4 recombinant protein (Position: A24-N92). Rat CCL4 shares 80% and 86% amino acid (aa) sequences identity with human and mouse CCL4, respectively.
Isotype	Rabbit IgG
Molecular Weight	36 kDa
Reactivity	Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	C-C motif chemokine 4;Macrophage inflammatory protein 1-beta;MIP-1-beta;Small-inducible cytokine A4;Ccl4;Mip1b, Scya4;
Tissue Specificity	Expression is increased in differentiated thyroid carcinomas compared to normal thyroid tissue and anaplastic thyroid tumors where expression is low or undetectable. Expression is found in thyrocytes but not in stromal cells (at protein level). .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P50230
Gene Id	116637
Gene Name	CCL4
Sequence	Belongs to the Wnt family.
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5 ug/ml, Rat Immunohistochemistry, 2-5 ug/ml, Rat

Reference	1. Irving SG, Zipfel PF, Balke J, McBride OW, Morton CC, Burd PR, Siebenlist U, Kelly K (June 1990). Nucleic Acids Res. 18 (11): 326170. 2. Bystry RS, Aluvihare V, Welch KA, Kallikourdis M, Betz AG (December 2001). "B cells and professional APCs recruit regulatory T cells via CCL4". Nat. Immunol. 2 (12): 112632. 3. Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P (December 1995). Science (joual) 270 (5243): 18115. 4. Kamin-Lewis R, Abdelwahab SF, Trang C, Baker A, DeVico AL, Gallo RC, Lewis GK (July 2001).

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007520-1	PB9064	-	100 ug	$370		Add to Cart
BHA21007520-2	PB9064-10ug	Sample	10 ug	$99		Add to Cart
BHA21007520-3	PB9064-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007520-4	PB9064-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007520-5	PB9064-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007520-6	PB9064-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007520-7	PB9064-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007520-8	PB9064-FITC	FITC	100 ug	$570		Add to Cart
BHA21007520-9	PB9064-HRP	HRP	100 ug	$570		Add to Cart
BHA21007520-10	PB9064-APC	APC	100 ug	$670		Add to Cart
BHA21007520-11	PB9064-PE	PE	100 ug	$670		Add to Cart
BHA21007520-12	PB9064-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007520-13	PB9064-carrier-free	carrier-free	100 ug	$370		Add to Cart

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