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Home / Primary Antibodies / Polyclonal Antibodies

Anti-LRP5 Antibody Picoband®

SKU : BHA21007438

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Mfr.No.	PA2273, PA2273-10ug, PA2273-Biotin, PA2273-Cy3, PA2273-Dylight488, PA2273-Dylight550, PA2273-Dylight594, PA2273-FITC, PA2273-HRP, PA2273-APC, PA2273-PE, PA2273-iFluor647, PA2273-carrier-free
Alternative Names	Low-density lipoprotein receptor-related protein 5
Background	Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. It is mapped to 11q13.2. LRP5 is a transmembrane low-density lipoprotein receptor that binds and intealizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with diabetes mellitus type 1 in humans. This protein plays a key role in skeletal homeostasis. In addition to that, the binding of axin to LRP5 is an important part of the Wnt signal transduction pathway, and it also acts as a target for the inhibitory effects of Dickkopf, another developmental protein, on Wnt signaling.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-LRP5 Antibody catalog # PA2273. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role i
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human LRP5, identical to the related mouse and rat sequences.
Isotype	Rabbit IgG
Molecular Weight	179 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Low-density lipoprotein receptor-related protein 5;LRP-5;LRP5;LR3, LRP7;
Tissue Specificity	Widely expressed, with the highest level of expression in the liver and in aorta. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O75197
Gene Name	LRP5
Sequence	Belongs to the LDLR family.
Subcellular Location	Membrane; Single-pass type I membrane protein. Endoplasmic reticulum . Chaperoned to the plasma membrane by MESD. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat, Human<br>

Reference	1. Hey PJ, Twells RC, Phillips MS, Yusuke Nakagawa, Brown SD, Kawaguchi Y, Cox R, Guochun Xie, Dugan V, Hammond H, Metzker ML, Todd JA, Hess JF (Oct 1998). "Cloning of a novel member of the low-absorbance lipoprotein receptor family". Gene 216 (1): 10311.<br /><br />2. "Entrez Gene: LRP5 low absorbance lipoprotein receptor-related protein 5"<br /><br />3. Mao, J., Wang, J., Liu, B., Pan, W., Farr, G. H., III, Flynn, C., Yuan, H., Takada, S., Kimelman, D., Li, L., Wu, D. Low-absorbance lipoprotein receptor-related protein-5 binds to axin and regulates the canonical Wnt signaling pathway. Molec. Cell 7: 801-809, 2001.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007438-1	PA2273	-	100 ug	$370		Add to Cart
BHA21007438-2	PA2273-10ug	Sample	10 ug	$99		Add to Cart
BHA21007438-3	PA2273-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007438-4	PA2273-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007438-5	PA2273-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007438-6	PA2273-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007438-7	PA2273-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007438-8	PA2273-FITC	FITC	100 ug	$570		Add to Cart
BHA21007438-9	PA2273-HRP	HRP	100 ug	$570		Add to Cart
BHA21007438-10	PA2273-APC	APC	100 ug	$670		Add to Cart
BHA21007438-11	PA2273-PE	PE	100 ug	$670		Add to Cart
BHA21007438-12	PA2273-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007438-13	PA2273-carrier-free	carrier-free	100 ug	$370		Add to Cart

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