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Home / Primary Antibodies / Polyclonal Antibodies

Anti-LOX 1/OLR1 Antibody Picoband®

SKU : BHA21007097

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Mfr.No.	PA1833, PA1833-10ug, PA1833-Biotin, PA1833-Cy3, PA1833-Dylight488, PA1833-Dylight550, PA1833-Dylight594, PA1833-FITC, PA1833-HRP, PA1833-APC, PA1833-PE, PA1833-iFluor647, PA1833-carrier-free
Alternative Names	Oxidized low-density lipoprotein receptor 1
Background	OLR1 (oxidized low density lipoprotein (lectin-like) receptor 1) also called CLEC8A, LOX-1, SCARE1, is a receptor protein which belongs to the C-type lectin superfamily. The OLR1 gene encodes a cell-surface endocytosis receptor for oxidized low density lipoprotein (OxLDL). The OLR1 gene is mapped on 12p13.2. Incubation of the cells with LDL had no effect on LOX1 expression, but incubation with OxLDL resulted in a dose-dependent increase in LOX1 mRNA and protein expression; however, very high concentrations of OxLDL caused a decrease in OxLDL expression, perhaps indicating toxic effects on endothelial cells. LOX1 was also expressed in macrophages, but not in vascular smooth muscle cells. The findings suggested a role for LOX1 in the pathophysiology of atherosclerotic cardiovascular disease. LOX1 expression was detected in all choroidal neovascular membranes, regardless of structure, whereas there was no evidence of LOX1 within the posterior segments of normal eyes. LOX1 plays an active role in the pathogenesis of choroidal neovascularization, especially in ARMD.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-LOX 1/OLR1 Antibody catalog # PA1833. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor that mediates the recognition, intealization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfu
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human LOX 1, different from the related rat sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	48-52 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Oxidized low-density lipoprotein receptor 1;Ox-LDL receptor 1;C-type lectin domain family 8 member A;Lectin-like oxidized LDL receptor 1;LOX-1;Lectin-like oxLDL receptor 1;hLOX-1;Lectin-type oxidized LDL receptor 1;Oxidized low-density lipoprotein receptor 1, soluble form;OLR1;CLEC8A, LOX1;
Tissue Specificity	Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P78380
Gene Name	OLR1
Sequence	Contains 1 C-type lectin domain.
Subcellular Location	Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted. A secreted form also exists. Localization to membrane rafts requires palmitoylation.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Aoyama, T., Sawamura, T., Furutani, Y., Matsuoka, R., Yoshida, M. C., Fujiwara, H., Masaki, T. Structure and chromosomal assignment of the human lectin-like oxidized low-absorbance-lipoprotein receptor-1 (LOX-1) gene. Biochem. J. 339: 177-184, 1999.<br /><br />2. Delneste, Y., Magistrelli, G., Gauchat, J.-F., Haeuw, J.-F., Aubry, J.-P., Nakamura, K., Kawakami-Honda, N., Goetsch, L., Sawamura, T., Bonnefoy, J.-Y., Jeannin, P. Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation. Immunity 17: 353-362, 2002.<br /><br />3. Luedecking-Zimmer, E., DeKosky, S. T., Chen, Q., Barmada, M. M., Kamboh, M. I. Investigation of oxidized LDL-receptor 1 (OLR1) as the candidate gene for Alzheimer's disease on chromosome 12. Hum. Genet. 111: 443-451, 2002.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007097-1	PA1833	-	100 ug	$370		Add to Cart
BHA21007097-2	PA1833-10ug	Sample	10 ug	$99		Add to Cart
BHA21007097-3	PA1833-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007097-4	PA1833-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007097-5	PA1833-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007097-6	PA1833-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007097-7	PA1833-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007097-8	PA1833-FITC	FITC	100 ug	$570		Add to Cart
BHA21007097-9	PA1833-HRP	HRP	100 ug	$570		Add to Cart
BHA21007097-10	PA1833-APC	APC	100 ug	$670		Add to Cart
BHA21007097-11	PA1833-PE	PE	100 ug	$670		Add to Cart
BHA21007097-12	PA1833-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007097-13	PA1833-carrier-free	carrier-free	100 ug	$370		Add to Cart

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