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Home / Primary Antibodies / Polyclonal Antibodies

Anti-liver Arginase/ARG1 Antibody Picoband®

SKU : BHA21002210

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Mfr.No.	A01106, A01106-10ug, A01106-Biotin, A01106-Cy3, A01106-Dylight488, A01106-Dylight550, A01106-Dylight594, A01106-FITC, A01106-HRP, A01106-APC, A01106-PE, A01106-iFluor647, A01106-carrier-free
Alternative Names	arginase, liver
Background	ARG1 (arginase, live) is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. The isoform encoded by ARG1, referred to as the liver, or A-I, isoform, contributes 98% of the arginase activity in liver but is also present in red cells. Using a rat liver ARG1 cDNA clone to probe a human liver cDNA library, Haraguchi et al. (1987) isolated and characterized a cDNA corresponding to the ARG1 gene. The ARG1 gene is mapped on 6q23.2 and the arginase gene contains 8 exons. By immunologic studies, 90% of the arginase in red blood cell and liver was precipitated by the antibody, whereas only 50% of the arginase in kidney, brain, and the gastrointestinal tract reacted with it. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-liver Arginase/ARG1 Antibody Picoband® catalog # A01106. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the ur
Host	Rabbit
Immunogen Region	E.coli-derived human liver Arginase/ARG1 recombinant protein (Position: E25-D183).
Isotype	Rabbit IgG
Molecular Weight	37 kDa
Reactivity	Human, Monkey, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Arginase-1; Liver-type arginase; Type I arginase; ARG1
Tissue Specificity	Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes (PMNs)). Also detected in macrophages mycobacterial granulomas. Expressed in group2 innate lymphoid cells (ILC2s) during lung disease.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P05089
Gene Id	383
Gene Name	ARG1
Subcellular Location	Cytoplasm. Cytoplasmic granule.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Western blot, 0.25-0.5 ug/ml<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml<br> ELISA, 0.1-0.5 ug/ml<br>

Reference	1. Cardoso, M. L., Martins, E., Vasconcelos, R., Vilarinho, L., Rocha, J. Identification of a novel R21X mutation in the liver-type arginase gene (ARG1) in four Portuguese patients with argininemia. Hum. Mutat. 14: 355-356, 1999.<br /><br />2. Grody, W. W., Dodson, A., Klein, D., Kern, R. M., Bassand, P., Cederbaum, S. D. Molecular genetic study of human arginase deficiency. (Abstract) Am. J. Hum. Genet. 45 (suppl.): A191 only, 1989.<br /><br />3. Haraguchi, Y., Takiguchi, M., Amaya, Y., Kawamoto, S., Matsuda, I., Mori, M. Molecular cloning and nucleotide sequence of cDNA for human liver arginase. Proc. Nat. Acad. Sci. 84: 412-415, 1987.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002210-1	A01106	-	100 ug	$370		Add to Cart
BHA21002210-2	A01106-10ug	Sample	10 ug	$99		Add to Cart
BHA21002210-3	A01106-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002210-4	A01106-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002210-5	A01106-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002210-6	A01106-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002210-7	A01106-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002210-8	A01106-FITC	FITC	100 ug	$570		Add to Cart
BHA21002210-9	A01106-HRP	HRP	100 ug	$570		Add to Cart
BHA21002210-10	A01106-APC	APC	100 ug	$670		Add to Cart
BHA21002210-11	A01106-PE	PE	100 ug	$670		Add to Cart
BHA21002210-12	A01106-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002210-13	A01106-carrier-free	carrier-free	100 ug	$370		Add to Cart

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