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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Lipocalin 2/LCN2 Antibody Picoband®

SKU : BHA21000504

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Mfr.No.	PB9608, PB9608-10ug, PB9608-Biotin, PB9608-Cy3, PB9608-Dylight488, PB9608-Dylight550, PB9608-Dylight594, PB9608-FITC, PB9608-HRP, PB9608-APC, PB9608-PE, PB9608-iFluor647, PB9608-carrier-free
Alternative Names	Neutrophil gelatinase-associated lipocalin
Background	Europhile gelatinase-associated lipocalin (NGAL) is a protein that in humans is encoded by the LCN2 gene. The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Lipocalin 2/LCN2 Antibody Picoband® catalog # PB9608. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial e
Host	Rabbit
Immunogen Region	E. coli-derived mouse Lipocalin 2 recombinant protein (Position: Q21-N200). Mouse Lipocalin 2 shares 62 % and 81.1 % amino acid (aa) sequence identity with human and rat Lipocalin 2, respectively.
Isotype	Rabbit IgG
Molecular Weight	22 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Neutrophil gelatinase-associated lipocalin;NGAL;Lipocalin-2;SV-40-induced 24P3 protein;Siderocalin LCN2;p25;Lcn2;
Tissue Specificity	Detected in lung, spleen, uterus, vagina and epididymis. .
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P11672
Gene Id	16819
Gene Name	Lcn2
Sequence	Belongs to the KIN17 family.
Subcellular Location	Secreted . Upon binding to the SLC22A17 (24p3R) receptor, it is intealized.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, By Heat Immunohistochemistry (Frozen Section), 0.5-1ug/ml ELISA, 0.1-0.5ug/ml Weste blot, 0.1-0.5ug/ml

Reference	1. Cowland JB, Borregaard N (October 1997). "Molecular characterization and patte of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans". Genomics 45 (1): 1723. 2. Chan P, Simon-Chazottes D, Mattei MG, Guenet JL, Salier JP (September 1994). "Comparative mapping of lipocalin genes in human and mouse: the four genes for complement C8 gamma chain, prostaglandin-D-synthase, oncogene-24p3, and progestagen-associated endometrial protein map to HSA9 and MMU2". Genomics 23 (1): 14550. 3. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A (December 2004). "Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron". Nature 432 (7019): 91721. 4. Kjeldsen L, Johnsen AH, Sengeløv H, Borregaard N (May 1993). "Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase". J. Biol. Chem. 268 (14): 1042532. 5. Nelson AM, Zhao W, Gilliland KL, Zaenglein AL, Liu W, Thiboutot DM (April 2008). 6. Schmidt-Ott KM, Mori K, Li JY, Kalandadze A, Cohen DJ, Devarajan P, Barasch J (February 2007). "Dual action of neutrophil gelatinase-associated lipocalin". J. Am. Soc. Nephrol. 18 (2): 40713.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000504-1	PB9608	100 ug	-	$370		Add to Cart
BHA21000504-2	PB9608-10ug	10 ug	Sample	$99		Add to Cart
BHA21000504-3	PB9608-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000504-4	PB9608-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000504-5	PB9608-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000504-6	PB9608-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000504-7	PB9608-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000504-8	PB9608-FITC	100 ug	FITC	$570		Add to Cart
BHA21000504-9	PB9608-HRP	100 ug	HRP	$570		Add to Cart
BHA21000504-10	PB9608-APC	100 ug	APC	$670		Add to Cart
BHA21000504-11	PB9608-PE	100 ug	PE	$670		Add to Cart
BHA21000504-12	PB9608-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000504-13	PB9608-carrier-free	100 ug	carrier-free	$370		Add to Cart

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