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Home / Primary Antibodies / Polyclonal Antibodies

Anti-LIM kinase 2/LIMK2 Antibody Picoband®

SKU : BHA21000617

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Mfr.No.	PB9717, PB9717-10ug, PB9717-Biotin, PB9717-Cy3, PB9717-Dylight488, PB9717-Dylight550, PB9717-Dylight594, PB9717-FITC, PB9717-HRP, PB9717-APC, PB9717-PE, PB9717-iFluor647, PB9717-carrier-free
Alternative Names	LIM domain kinase 2
Background	LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene. There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in tu, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-LIM kinase 2/LIMK2 Antibody Picoband® catalog # PB9717. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human LIM kinase 2, different from the related mouse sequence by four amino acids, and from the related rat sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	72 kDa
Reactivity	Human, Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	LIM domain kinase 2;LIMK-2;2.7.11.1;LIMK2;
Tissue Specificity	Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P53671
Gene Id	3985
Gene Name	LIMK2
Subcellular Location	Isoform LIMK2a: Cytoplasm. Nucleus. Isoform LIMK2a is distributed in the cytoplasm and the nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse

Reference	1. "Entrez Gene: LIMK2 LIM domain kinase 2". 2. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22".Nature 402 (6761): 48995. 3. Okano I, Hiraoka J, Otera H, Nunoue K, Ohashi K, Iwashita S, Hirai M, Mizuno K (Dec 1995). "Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs". The Joual of Biological Chemistry 270 (52): 3132130.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000617-1	PB9717	100 ug	-	$370		Add to Cart
BHA21000617-2	PB9717-10ug	10 ug	Sample	$99		Add to Cart
BHA21000617-3	PB9717-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000617-4	PB9717-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000617-5	PB9717-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000617-6	PB9717-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000617-7	PB9717-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000617-8	PB9717-FITC	100 ug	FITC	$570		Add to Cart
BHA21000617-9	PB9717-HRP	100 ug	HRP	$570		Add to Cart
BHA21000617-10	PB9717-APC	100 ug	APC	$670		Add to Cart
BHA21000617-11	PB9717-PE	100 ug	PE	$670		Add to Cart
BHA21000617-12	PB9717-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000617-13	PB9717-carrier-free	100 ug	carrier-free	$370		Add to Cart

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