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Home / Primary Antibodies / Polyclonal Antibodies

Anti-LDL Receptor/LDLR Antibody Picoband®

SKU : BHA21002655

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Mfr.No.	A00076-2, A00076-2-10ug, A00076-2-Biotin, A00076-2-Cy3, A00076-2-Dylight488, A00076-2-Dylight550, A00076-2-Dylight594, A00076-2-FITC, A00076-2-HRP, A00076-2-APC, A00076-2-PE, A00076-2-iFluor647, A00076-2-carrier-free
Alternative Names	low density lipoprotein receptor
Background	In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. It is mapped to 19p13.2. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alteate splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-LDL Receptor/LDLR Antibody Picoband® catalog # A00076-2. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be intealized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (Microbial infection) Acts as a receptor
Host	Rabbit
Immunogen Region	E.coli-derived human LDL Receptor/LDLR recombinant protein (Position: Q35-D843).
Isotype	Rabbit IgG
Molecular Weight	130 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Low-density lipoprotein receptor; LDL receptor; LDLR
Tissue Specificity	Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P01130
Gene Id	3949
Gene Name	LDLR
Subcellular Location	Lysosome. Golgi apparatus. Cell membrane. Single-pass type I membrane protein. Early endosome. Late endosome. Clathrin-coated pit.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human, Rat<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Aalto-Setala, K., Helve, E., Kovanen, P. T., Kontula, K. Finnish type of low absorbance lipoprotein receptor gene mutation (FH-Helsinki) deletes exons encoding the carboxy-terminal part of the receptor and creates an intealization-defective phenotype. J. Clin. Invest. 84: 499-505, 1989.<br /><br />2. Aalto-Setala, K., Koivisto, U.-M., Miettinen, T. A., Gylling, H., Kesaniemi, Y. A., Savolainen, M., Pyorala, K., Ebeling, T., Mononen, I., Turtola, H., Viikari, J., Kontula, K. Prevalence and geographical distribution of major LDL receptor gene rearrangements in Finland. J. Inte. Med. 231: 227-234, 1992.<br /><br />3. Agnello, V., Abel, G., Elfahal, M., Knight, G. B., Zhang, Q.-X. Hepatitis C virus and other flaviviridae viruses enter cells via low absorbance lipoprotein receptor. Proc. Nat. Acad. Sci. 96: 12766-12771, 1999.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002655-1	A00076-2	-	100 ug	$370		Add to Cart
BHA21002655-2	A00076-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002655-3	A00076-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002655-4	A00076-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002655-5	A00076-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002655-6	A00076-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002655-7	A00076-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002655-8	A00076-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002655-9	A00076-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002655-10	A00076-2-APC	APC	100 ug	$670		Add to Cart
BHA21002655-11	A00076-2-PE	PE	100 ug	$670		Add to Cart
BHA21002655-12	A00076-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002655-13	A00076-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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