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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Lck Antibody Picoband®

SKU : BHA21000710

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Mfr.No.	PB9808, PB9808-10ug, PB9808-Biotin, PB9808-Cy3, PB9808-Dylight488, PB9808-Dylight550, PB9808-Dylight594, PB9808-FITC, PB9808-HRP, PB9808-APC, PB9808-PE, PB9808-iFluor647, PB9808-carrier-free
Alternative Names	Tyrosine-protein kinase Lck
Background	Lck (or lymphocyte-specific protein tyrosine kinase) is a 56 kDa protein that is found inside specializedcells of the immune system called lymphocytes. The human LCK gene is mapped to chromosome 1p35-p32. This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alteatively spliced variants, encoding the same protein, have been described.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Lck Antibody Picoband® catalog # PB9808. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction path
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Lck, different from the related mouse and rat sequences by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	58 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tyrosine-protein kinase Lck;2.7.10.2;Leukocyte C-terminal Src kinase;LSK;Lymphocyte cell-specific protein-tyrosine kinase;Protein YT16;Proto-oncogene Lck;T cell-specific protein-tyrosine kinase;p56-LCK;LCK;
Tissue Specificity	Expressed specifically in lymphoid cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P06239
Gene Id	3932
Gene Name	LCK
Subcellular Location	Cytoplasm . Cell membrane ; Lipid-anchor ; Cytoplasmic side . Present in lipid rafts in an inactive form.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Mouse Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Anderson, S. J., Levin, S. D., Perlmutter, R. M. Protein tyrosine kinase p56(lck) controls allelic exclusion of T-cell receptor beta-chain genes. Nature 365: 552-554, 1993. 2. Buett, R. C., David, J.-C., Harden, A. M., Le Beau, M. M., Rowley, J. D., Diaz, M. O. The LCK gene is involved in the t(1;7)(p34;q34) in the T-cell acute lymphoblastic leukemia derived cell line, HSB-2. Genes Chromosomes Cancer 3: 461-467, 1991. 3. Marth, J. D., Disteche, C., Pravtcheva, D., Ruddle, F., Krebs, E. G., Perlmutter, R. M. Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas. Proc. Nat. Acad. Sci. 83: 7400-7404, 1986.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000710-1	PB9808	100 ug	-	$370		Add to Cart
BHA21000710-2	PB9808-10ug	10 ug	Sample	$99		Add to Cart
BHA21000710-3	PB9808-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000710-4	PB9808-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000710-5	PB9808-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000710-6	PB9808-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000710-7	PB9808-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000710-8	PB9808-FITC	100 ug	FITC	$570		Add to Cart
BHA21000710-9	PB9808-HRP	100 ug	HRP	$570		Add to Cart
BHA21000710-10	PB9808-APC	100 ug	APC	$670		Add to Cart
BHA21000710-11	PB9808-PE	100 ug	PE	$670		Add to Cart
BHA21000710-12	PB9808-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000710-13	PB9808-carrier-free	100 ug	carrier-free	$370		Add to Cart

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