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Home / Primary Antibodies / Polyclonal Antibodies

Anti-LARG/ARHGEF12 Antibody Picoband®

SKU : BHA21004221

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Mfr.No.	A06802-2, A06802-2-10ug, A06802-2-Biotin, A06802-2-Cy3, A06802-2-Dylight488, A06802-2-Dylight550, A06802-2-Dylight594, A06802-2-FITC, A06802-2-HRP, A06802-2-APC, A06802-2-PE, A06802-2-iFluor647, A06802-2-carrier-free
Alternative Names	PR/SET domain 5
Background	Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-LARG/ARHGEF12 Antibody Picoband® catalog # A06802-2. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (
Host	Rabbit
Immunogen Region	E.coli-derived human LARG/ARHGEF12 recombinant protein (Position: T4-S254).
Isotype	Rabbit IgG
Molecular Weight	220 kDa
Reactivity	Human, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	PR domain zinc finger protein 5; PR domain-containing protein 5; PRDM5; PFM2
Tissue Specificity	Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9NZN5
Gene Id	23365
Gene Name	ARHGEF12
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human, Rat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Goulimari, P., Knieling, H., Engel, U., Grosse, R. LARG and mDia1 link G-alpha-12/13 to cell polarity and microtubule dynamics. Molec. Biol. Cell 19: 30-40, 2008. <br /><br />2. Kourlas, P. J., Strout, M. P., Becknell, B., Veronese, M. L., Croce, C. M., Theil, K. S., Krahe, R., Ruutu, T., Knuutila, S., Bloomfield, C. D., Caligiuri, M. A. Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia. Proc. Nat. Acad. Sci. 97: 2145-2150, 2000. <br /><br />3. Martz, M. K., Grabocka, E., Beeharry, N., Yen, T. J., Wedegaertner, P. B. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission. Molec. Biol. Cell 24: 2785-2794, 2013.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004221-1	A06802-2	-	100 ug	$370		Add to Cart
BHA21004221-2	A06802-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004221-3	A06802-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004221-4	A06802-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004221-5	A06802-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004221-6	A06802-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004221-7	A06802-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004221-8	A06802-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004221-9	A06802-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004221-10	A06802-2-APC	APC	100 ug	$670		Add to Cart
BHA21004221-11	A06802-2-PE	PE	100 ug	$670		Add to Cart
BHA21004221-12	A06802-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004221-13	A06802-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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