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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Laminin subunit gamma-2 LAMC2 Antibody Picoband®

SKU : BHA21006903

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Mfr.No.	PA1582, PA1582-10ug, PA1582-Biotin, PA1582-Cy3, PA1582-Dylight488, PA1582-Dylight550, PA1582-Dylight594, PA1582-FITC, PA1582-HRP, PA1582-APC, PA1582-PE, PA1582-iFluor647, PA1582-carrier-free
Alternative Names	Laminin subunit gamma-2
Background	Laminin gamma2, Laminin subunit gamma-2, is a protein that in humans is encoded by the LAMC2 gene. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly though to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Laminin subunit gamma-2 LAMC2 Antibody catalog # PA1582. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell- scatt
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human LAMC2, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	131 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Laminin subunit gamma-2;Cell-scattering factor 140 kDa subunit;CSF 140 kDa subunit;Epiligrin subunit gamma;Kalinin subunit gamma;Kalinin/nicein/epiligrin 100 kDa subunit;Ladsin 140 kDa subunit;Laminin B2t chain;Laminin-5 subunit gamma;Large adhesive scatter factor 140 kDa subunit;Nicein subunit gamma;LAMC2;LAMB2T, LAMNB2;
Tissue Specificity	The large variant is expressed only in specific epithelial cells of embryonic and neonatal tissues. In 17-week old embryo the small variant is found in cerebral cortex, lung, and distal tubes of kidney, but not in epithelia except for distal tubuli.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q13753
Gene Name	LAMC2
Sequence	Contains 8 laminin EGF-like domains.
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane. Major component.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>

Reference	1. Aberdam, D., Galliano, M.-F., Vailly, J., Pulkkinen, L., Bonifas, J., Christiano, A. M., Tryggvason, K., Uitto, J., Epstein, E. H., Jr., Ortonne, J.-P., Meneguzzi, G.Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the gamma-2 subunit of nicein/kalinin (laminin-5).Nature Genet. 6: 299-304, 1994.<br /><br />2. Airenne, T., Haakana, H., Sainio, K., Kallunki, T., Kallunki, P., Sariola, H., Tryggvason, K.Structure of the human laminin gamma-2 chain gene (LAMC2): alteative splicing with different tissue distribution of two transcripts.Genomics 32: 54-64, 1996.<br /><br />3. Baudoin, C., Miquel, C., Gagnoux-Palacios, L., Pulkkinen, L., Christiano, A. M., Uitto, J., Tadini, G., Ortonne, J.-P., Meneguzzi, G.A novel homozygous nonsense mutation in the LAMC2 gene in patients with the Herlitz junctional epidermolysis bullosa.Hum. Molec. Genet. 3: 1909-1910, 1994.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006903-1	PA1582	-	100 ug	$370		Add to Cart
BHA21006903-2	PA1582-10ug	Sample	10 ug	$99		Add to Cart
BHA21006903-3	PA1582-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006903-4	PA1582-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006903-5	PA1582-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006903-6	PA1582-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006903-7	PA1582-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006903-8	PA1582-FITC	FITC	100 ug	$570		Add to Cart
BHA21006903-9	PA1582-HRP	HRP	100 ug	$570		Add to Cart
BHA21006903-10	PA1582-APC	APC	100 ug	$670		Add to Cart
BHA21006903-11	PA1582-PE	PE	100 ug	$670		Add to Cart
BHA21006903-12	PA1582-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006903-13	PA1582-carrier-free	carrier-free	100 ug	$370		Add to Cart

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