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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Lamin A + C/LMNA Antibody Picoband®

SKU : BHA21006661

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Mfr.No.	PA1103, PA1103-10ug, PA1103-Biotin, PA1103-Cy3, PA1103-Dylight488, PA1103-Dylight550, PA1103-Dylight594, PA1103-FITC, PA1103-HRP, PA1103-APC, PA1103-PE, PA1103-iFluor647, PA1103-carrier-free
Alternative Names	Prelamin-A/C
Background	Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A,B and C. The lamin A/C (LMNA) gene contains 12 exons. Alteative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Lamin A + C/LMNA Antibody catalog # PA1103. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Lamin A/C, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	70-74 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Prelamin-A/C;Lamin-A/C;70 kDa lamin;Renal carcinoma antigen NY-REN-32;LMNA;LMN1;
Tissue Specificity	In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P02545
Gene Name	LMNA
Sequence	Belongs to the intermediate filament family.
Subcellular Location	Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Faesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the faesyl group produces mature lamin- A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-faesylated prelamin-A/C.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, ICC, WB
Description	Immunocytochemistry , 0.5-1ug/ml, Human, Mouse, Rat<br>Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Lammerding, J.; Schulze, P. C.; Takahashi, T.; Kozlov, S.; Sullivan, T.; Kamm, R. D.; Stewart, C. L.; Lee, R. T. : Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. J. Clin. Invest. 113: 370-378, 2004.<br /><br />2. Lin, F.; Worman, H. J. : Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C. J. Biol. Chem. 268: 16321-16326, 1993.<br /><br />3. Wydner, K. L.; McNeil, J. A.; Lin, F.; Worman, H. J.; Lawrence, J. B. : Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization. Genomics 32: 474-478, 1996.<br /><br /><br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006661-1	PA1103	-	100 ug	$370		Add to Cart
BHA21006661-2	PA1103-10ug	Sample	10 ug	$99		Add to Cart
BHA21006661-3	PA1103-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006661-4	PA1103-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006661-5	PA1103-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006661-6	PA1103-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006661-7	PA1103-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006661-8	PA1103-FITC	FITC	100 ug	$570		Add to Cart
BHA21006661-9	PA1103-HRP	HRP	100 ug	$570		Add to Cart
BHA21006661-10	PA1103-APC	APC	100 ug	$670		Add to Cart
BHA21006661-11	PA1103-PE	PE	100 ug	$670		Add to Cart
BHA21006661-12	PA1103-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006661-13	PA1103-carrier-free	carrier-free	100 ug	$370		Add to Cart

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