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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Lactate Dehydrogenase B/LDHB Antibody Picoband®

SKU : BHA21000981

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Mfr.No.	PB10076, PB10076-10ug, PB10076-Biotin, PB10076-Cy3, PB10076-Dylight488, PB10076-Dylight550, PB10076-Dylight594, PB10076-FITC, PB10076-HRP, PB10076-APC, PB10076-PE, PB10076-iFluor647, PB10076-carrier-free
Alternative Names	L-lactate dehydrogenase B chain
Background	The LDHB gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alteatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alteative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Lactate Dehydrogenase B/LDHB Antibody Picoband® catalog # PB10076. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting an
Host	Rabbit
Immunogen Region	E. coli-derived human LDHB recombinant protein (Position: E237-L334). Human LDHB shares 98% amino acid (aa) sequence identity with both mouse and rat LDHB.
Isotype	Rabbit IgG
Molecular Weight	37 kDa
Reactivity	Human, Monkey, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	L-lactate dehydrogenase B chain;LDH-B;1.1.1.27;LDH heart subunit;LDH-H;Renal carcinoma antigen NY-REN-46;LDHB;
Tissue Specificity	Low levels in brain. Very weak expression found in heart and muscle. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P07195
Gene Id	3945
Gene Name	LDHB
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Monkey, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Markert, C. L. Lactate dehydrogenase: biochemistry and function of lactate dehydrogenase. Cell Biochem. Func. 2: 131-134, 1984. 2. Okumura, N., Terasawa, F., Ueno, I., Oki, K., Yamauchi, K., Hidaka, H., Tozuka, M., Okura, M., Katsuyama, T. Genetic analyses in homozygous and heterozygous variants of lactate dehydrogenase-B (H) subunit: LD-B Matsumoto I and II (LD-B W323R). Clin. Chim. Acta 287: 163-171, 1999.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000981-1	PB10076	100 ug	-	$370		Add to Cart
BHA21000981-2	PB10076-10ug	10 ug	Sample	$99		Add to Cart
BHA21000981-3	PB10076-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000981-4	PB10076-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000981-5	PB10076-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000981-6	PB10076-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000981-7	PB10076-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000981-8	PB10076-FITC	100 ug	FITC	$570		Add to Cart
BHA21000981-9	PB10076-HRP	100 ug	HRP	$570		Add to Cart
BHA21000981-10	PB10076-APC	100 ug	APC	$670		Add to Cart
BHA21000981-11	PB10076-PE	100 ug	PE	$670		Add to Cart
BHA21000981-12	PB10076-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000981-13	PB10076-carrier-free	100 ug	carrier-free	$370		Add to Cart

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