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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Kv1.1 potassium channel/KCNA1 Antibody Picoband®

SKU : BHA21007454

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Mfr.No.	PA2296, PA2296-10ug, PA2296-Biotin, PA2296-Cy3, PA2296-Dylight488, PA2296-Dylight550, PA2296-Dylight594, PA2296-FITC, PA2296-HRP, PA2296-APC, PA2296-PE, PA2296-iFluor647, PA2296-carrier-free
Alternative Names	Potassium voltage-gated channel subfamily A member 1
Background	Potassium voltage-gated channel subfamily A member 1, also known as Kv1.1, is a shaker related voltage-gated potassium channel that in humans is encoded by the KCNA1 gene. It is mapped to 12p13.32. The protein functions as a potassium selective channel through which the potassium ion may pass through in consensus with the electrochemical gradient. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Kv1.1 potassium channel/KCNA1 Antibody catalog # PA2296. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney (PubMed:19903818). Contributes to the regulation of the membrane potentia
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Kv1.1 potassium channel, different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids .
Isotype	Rabbit IgG
Molecular Weight	56 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Potassium voltage-gated channel subfamily A member 1;Voltage-gated K (+) channel HuKI ;Voltage-gated potassium channel HBK1 ;Voltage-gated potassium channel subunit Kv1.1;KCNA1;
Tissue Specificity	Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297). Detected in the islet of Langerhans (PubMed:21483673). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q09470
Gene Name	KCNA1
Subcellular Location	Cell membrane ; Multi- pass membrane protein . Membrane . Cell projection, axon . Cytoplasmic vesicle . Perikaryon . Endoplasmic reticulum . Cell projection, dendrite . Cell junction . Cell junction, synapse . Cell junction, synapse, presynaptic cell membrane . Homotetrameric KCNA1 is primarily located in the endoplasmic reticulum. Interaction with KCNA2 and KCNAB2 or with KCNA4 and KCNAB2 promotes expression at the cell membrane (By similarity). Detected at axon terminals (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Albrecht B, Weber K, Pongs O (1995). "Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13". Recept. Channels 3 (3): 21320.<br /><br />2. Curran ME, Landes GM, Keating MT (1992). "Molecular cloning, characterization, and genomic localization of a human potassium channel gene". Genomics 12 (4): 72937.<br /><br />3. "Entrez Gene: KCNA1 potassium voltage-gated channel"<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007454-1	PA2296	-	100 ug	$370		Add to Cart
BHA21007454-2	PA2296-10ug	Sample	10 ug	$99		Add to Cart
BHA21007454-3	PA2296-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007454-4	PA2296-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007454-5	PA2296-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007454-6	PA2296-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007454-7	PA2296-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007454-8	PA2296-FITC	FITC	100 ug	$570		Add to Cart
BHA21007454-9	PA2296-HRP	HRP	100 ug	$570		Add to Cart
BHA21007454-10	PA2296-APC	APC	100 ug	$670		Add to Cart
BHA21007454-11	PA2296-PE	PE	100 ug	$670		Add to Cart
BHA21007454-12	PA2296-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007454-13	PA2296-carrier-free	carrier-free	100 ug	$370		Add to Cart

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