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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Ku80/XRCC5 Antibody Picoband®

SKU : BHA21000358

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Mfr.No.	PB9464, PB9464-10ug, PB9464-Biotin, PB9464-Cy3, PB9464-Dylight488, PB9464-Dylight550, PB9464-Dylight594, PB9464-FITC, PB9464-HRP, PB9464-APC, PB9464-PE, PB9464-iFluor647, PB9464-carrier-free
Alternative Names	X-ray repair cross-complementing protein 5
Background	XRCC5 (X-ray Repair,Complementing Defective ,In Chinese Hamster, 5), also known as Ku80 or Ku86, is a protein that in humans, is encoded by the XRCC5 gene. The XRCC5 gene encodes the 80-kD subunit of the Ku autoantigen, a heterodimer which contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous end joining (NHEJ) pathway. The XRCC5 gene is mapped to 2q35. Human colon cancer cells heterozygous for Ku86 are haploinsufficient with an increase in polyploid cells, a reduction in cell proliferation, elevated p53 levels, and a slight hypersensitivity to ionizing radiation. Functional inactivation of the second Ku86 allele results in cells with a drastically reduced doubling time. The Ku86 locus is essential in human somatic tissue culture cells by experiments demonstration. A rare microsatellite polymorphism in XRCC5 is associated with cancer in patients of varying radiosensitivity.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Ku80/XRCC5 Antibody Picoband® catalog # PB9464. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' ion. Binding to
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Ku80, different from the related mouse sequence by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	83 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	X-ray repair cross-complementing protein 5;3.6.4.-;86 kDa subunit of Ku antigen;ATP-dependent DNA helicase 2 subunit 2;ATP-dependent DNA helicase II 80 kDa subunit;CTC box-binding factor 85 kDa subunit;CTC85;CTCBF;DNA repair protein XRCC5;Ku80;Ku86;Lupus Ku autoantigen protein p86;Nuclear factor IV;Thyroid-lupus autoantigen;TLAA;X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining);XRCC5;G22P2;
Tissue Specificity	Expressed in plasma cells in rheumatoid synovium (PubMed:11460154). Over-expressed in primary breast cancer and metastatic breast cancer cells (PubMed:25280941). Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells (PubMed:19416856). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P13010
Gene Id	7520
Gene Name	XRCC5
Sequence	Belongs to the ku80 family.
Subcellular Location	Nucleus. Nucleus, nucleolus. Chromosome.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Blunt, T., Taccioli, G. E., Priestley, A., Hafezparast, M., McMillan, T., Liu, J., Cole, C. C., White, J., Alt, F. W., Jackson, S. P., Schurr, E., Lehmann, A. R., Jeggo, P. A. A YAC contig encompassing the XRCC5 (Ku80) DNA repair gene and complementation defective cells by YAC protoplast fusion. Genomics 30: 320-328, 1995. 2. Chen, D. J., Marrone, B. L., Nguyen, T., Stackhouse, M., Zhao, Y., Siciliano, M. J. Regional assignment of a human DNA repair gene (XRCC5) to 2q35 by x-ray hybrid mapping. Genomics 21: 423-427, 1994.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000358-1	PB9464	100 ug	-	$370		Add to Cart
BHA21000358-2	PB9464-10ug	10 ug	Sample	$99		Add to Cart
BHA21000358-3	PB9464-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000358-4	PB9464-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000358-5	PB9464-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000358-6	PB9464-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000358-7	PB9464-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000358-8	PB9464-FITC	100 ug	FITC	$570		Add to Cart
BHA21000358-9	PB9464-HRP	100 ug	HRP	$570		Add to Cart
BHA21000358-10	PB9464-APC	100 ug	APC	$670		Add to Cart
BHA21000358-11	PB9464-PE	100 ug	PE	$670		Add to Cart
BHA21000358-12	PB9464-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000358-13	PB9464-carrier-free	100 ug	carrier-free	$370		Add to Cart

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