JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
orders@biohippo.com

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Primary Antibodies / Polyclonal Antibodies

Anti-KRIT1 Antibody Picoband®

SKU : BHA21000979

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Request More Infos

Boster

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

orders@biohippo.com

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	PB10074, PB10074-10ug, PB10074-Biotin, PB10074-Cy3, PB10074-Dylight488, PB10074-Dylight550, PB10074-Dylight594, PB10074-FITC, PB10074-HRP, PB10074-APC, PB10074-PE, PB10074-iFluor647, PB10074-carrier-free
Alternative Names	Krev interaction trapped protein 1
Background	Krev interaction trapped protein 1 (KRIT1) is a protein that in humans is encoded by the CCM1 gene. This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral caveous malformations. Multiple alteatively spliced transcript variants have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-KRIT1 Antibody Picoband® catalog # PB10074. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting an
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human KRIT1, different from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	84 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Krev interaction trapped protein 1;Krev interaction trapped 1;Cerebral caveous malformations 1 protein;KRIT1;CCM1;
Tissue Specificity	Low levels in brain. Very weak expression found in heart and muscle. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O00522
Gene Id	889
Gene Name	KRIT1
Subcellular Location	Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell junction. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. Association with RAP1 relocalizes KRIT1 from microtubules to cell junction membranes. Translocates from the cytoplasm along microtubules to the cell membrane in a ITGB1BP1- dependent manner.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. Eerola I, McIntyre B, Vikkula M (Feb 2001). "Identification of eight novel 5'-exons in cerebral capillary malformation gene-1 (CCM1) encoding KRIT1".Biochimica et Biophysica Acta 1517 (3): 4647. 2. Pagenstecher A, Stahl S, Sure U, Felbor U (Mar 2009)."A two-hit mechanism causes cerebral caveous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cells". Human Molecular Genetics 18 (5): 9118.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000979-1	PB10074	100 ug	-	$370		Add to Cart
BHA21000979-2	PB10074-10ug	10 ug	Sample	$99		Add to Cart
BHA21000979-3	PB10074-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000979-4	PB10074-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000979-5	PB10074-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000979-6	PB10074-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000979-7	PB10074-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000979-8	PB10074-FITC	100 ug	FITC	$570		Add to Cart
BHA21000979-9	PB10074-HRP	100 ug	HRP	$570		Add to Cart
BHA21000979-10	PB10074-APC	100 ug	APC	$670		Add to Cart
BHA21000979-11	PB10074-PE	100 ug	PE	$670		Add to Cart
BHA21000979-12	PB10074-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000979-13	PB10074-carrier-free	100 ug	carrier-free	$370		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.