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Home / Primary Antibodies / Polyclonal Antibodies

Anti-KCNK1 (TWIK-1) (extracellular) Antibody

SKU : BHA21301015

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Alomone Labs

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Mfr.No.	APC-110, APC-110-CF_0.2 ml, APC-110_0.2 ml, APC-110_25 mcl, APC-110_50 mcl
Lead Time	1-2 Business Days
Immunogen Species	Human
Background	KCNK1 (also named TWIK-1 or K2P1.1) is a member of the 2-pore (2P) domain K+ channels family that, currently, includes 16 members. These channels show little time- or voltage-dependence and are considered to be "leak" or "background" K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N- and C termini. K2P channels are regulated by diverse physical and chemical stimuli including temperature, pH, mechanical stretch, inhalation anesthetics, etc. but are insensitive to the classical K+ channel blockers.KCNK1 was the first of the K2P channels to be identified and as its original name indicates (Tandem of P domains in a Weak Inward rectifier K+ channel) the channel behaves as a weak inward rectifier when expressed in heterologous systems. The channel is ubiquitously expressed with the most prominent expression in the brain, kidney and heart.
Clonality	Polyclonal
Description	Alomone Labs is pleased to offer a highly specific antibody directed against an epitope of the human K2P1.1 channel. Anti-KCNK1 (TWIK-1) (extracellular) Antibody (#APC-110) can be used in western blot and immunohistochemistry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting KCNK1 in living cells. It has been designed to recognize KCNK1 from mouse, rat and human samples.
Formulation	PBS pH7.4
Host	Rabbit
Immunogen Region	Extracellular, near the P1 loop
Isotype	Rabbit IgG
Reactivity	Human, Rat, Mouse
Reconstitution	0.2 ml double distilled water (DDW).
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	Potassium channel subfamily K member 1, Inward rectifying K+ channel protein TWIK-1, K2P1.1, HOHO1, KCNO1
UNSPSC Code	41116161
Note	Homology: Rat, mouse, pig - identical Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Negative Control: BLP-PC110 Specifictiy: KCNK1 Is Toxin: No Standard quality control of each lot: Western blot analysis Antigen preadsorption control: 1 ug peptide per 1 ug antibody

Accession Number	O00180
Gene Id	3775
Target	Potassium channel subfamily K member 1, Inward rectifying K+ channel protein TWIK-1, K2P1.1, HOHO1, KCNO1
Sequence	RQELRKLKRRFLEEHEC, corresponding to amino acid residues 53-69 of human KCNK1

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4.
Preservative	No Preservative
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IF, IHC, WB
Dilution	Contact Alomone for information

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21301015-1	APC-110-CF_0.2 ml	0.2 ml(Carrier Free)	$994		Add to Cart
BHA21301015-2	APC-110_0.2 ml	0.2 ml	$795		Add to Cart
BHA21301015-3	APC-110_25 mcl	25 mcl	$597		Add to Cart
BHA21301015-4	APC-110_50 mcl	50 mcl	$697		Add to Cart

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