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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Kallikrein 1/KLK1 Antibody Picoband®

SKU : BHA21006998

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Mfr.No.	PA1709, PA1709-10ug, PA1709-Biotin, PA1709-Cy3, PA1709-Dylight488, PA1709-Dylight550, PA1709-Dylight594, PA1709-FITC, PA1709-HRP, PA1709-APC, PA1709-PE, PA1709-iFluor647, PA1709-carrier-free
Alternative Names	Kallikrein-1
Background	KLK1 (KALLIKREIN 1), also called KLKR, is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family. KLK1 is a serine protease that generates Lys-bradykinin by specific proteolysis of kininogen-1. The KLK1 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19 and its exact cytogenetic location is 19q13.33. The KLK1 gene contains 5 coding exons. And KLK1 is the most centromeric gene in the cluster. Mice lacking tissue kallikrein are unable to generate significant levels of kinins in most tissues and develop cardiovascular abnormalities early in adulthood despite normal blood pressure. The protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Kallikrein 1/KLK1 Antibody catalog # PA1709. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of mouse Kallikrein 1.
Isotype	Rabbit IgG
Molecular Weight	29 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Kallikrein-1;3.4.21.35;Glandular kallikrein K1;KAL-B;Renal kallikrein;Tissue kallikrein-6;mGK-6;Klk1;Klk-6, Klk6;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P15947
Gene Name	KLK1
Sequence	Belongs to the peptidase S1 family. Kallikrein subfamily.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Mouse, Rat<br>

Reference	1. Azizi, M., Boutouyrie, P., Bissery, A., Agharazii, M., Verbeke, F., Ste, N., Bura-Riviere, A., Laurent, S., Alhenc-Gelas, F., Jeunemaitre, X. Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans. J. Clin. Invest. 115: 780-787, 2005. <br /><br />2. Baker, A. R., Shine, J. Human kidney kallikrein: cDNA cloning and sequence analysis. DNA 4: 445-450, 1985.<br /><br />3. Clements J, Hooper J, Dong Y, Harvey T (2001). "The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions".<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006998-1	PA1709	-	100 ug	$370		Add to Cart
BHA21006998-2	PA1709-10ug	Sample	10 ug	$99		Add to Cart
BHA21006998-3	PA1709-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006998-4	PA1709-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006998-5	PA1709-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006998-6	PA1709-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006998-7	PA1709-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006998-8	PA1709-FITC	FITC	100 ug	$570		Add to Cart
BHA21006998-9	PA1709-HRP	HRP	100 ug	$570		Add to Cart
BHA21006998-10	PA1709-APC	APC	100 ug	$670		Add to Cart
BHA21006998-11	PA1709-PE	PE	100 ug	$670		Add to Cart
BHA21006998-12	PA1709-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006998-13	PA1709-carrier-free	carrier-free	100 ug	$370		Add to Cart

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