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Home / Primary Antibodies / Polyclonal Antibodies

Anti-JRK Antibody Picoband®

SKU : BHA21002928

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Mfr.No.	A15261, A15261-10ug, A15261-Biotin, A15261-Cy3, A15261-Dylight488, A15261-Dylight550, A15261-Dylight594, A15261-FITC, A15261-HRP, A15261-APC, A15261-PE, A15261-iFluor647, A15261-carrier-free
Alternative Names	RING finger protein 186
Background	This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB). Inactivation of the related gene in mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-JRK Antibody Picoband® catalog # A15261. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completio
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human JRK, which shares 93.8% and 87.5% amino acid (aa) sequence identity with mouse and rat JRK, respectively.
Isotype	Rabbit IgG
Molecular Weight	65 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	RING finger protein 186;RNF186;
Tissue Specificity	Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	O75564
Gene Id	8629
Gene Name	JRK
Subcellular Location	Membrane ; Multi-pass membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.25-0.5ug/ml, Human<br>

Reference	1. Donovan, G. P., Harden, C., Gal, J., Ho, L., Sibille, E., Trifiletti, R., Gudas, L. J., Toth, M. Sensitivity to jerky gene dosage underlies epileptic seizures in mice. J. Neurosci. 17: 4562-4569, 1997.<br /><br />2. Moore, T., Hecquet, S., McLellann, A., Ville, D., Grid, D., Picard, F., Moulard, B., Asherson, P., Makoff, A. J., McCormick, D., Nashef, L., Froguel, P., Arzimanoglou, A., LeGue, E., Bailleul, B. Polymorphism analysis of JRK/JH8, the human homologue of mouse jerky, and description of a rare mutation in a case of CAE evolving to JME. Epilepsy Res. 46: 157-167, 2001.<br /><br />3. Morita, R., Miyazaki, E., Fong, C. G., Chen, X.-N., Korenberg, J. R., Delgado-Escueta, A. V., Yamakawa, K. JH8, a gene highly homologous to the mouse jerky gene, maps to the region for childhood absence epilepsy on 8q24. Biochem. Biophys. Res. Commun. 248: 307-314, 1998. Note: Erratum: Biochem. Biophys. Res. Commun. 250: 536 only, 1998.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002928-1	A15261	-	100 ug	$370		Add to Cart
BHA21002928-2	A15261-10ug	Sample	10 ug	$99		Add to Cart
BHA21002928-3	A15261-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002928-4	A15261-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002928-5	A15261-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002928-6	A15261-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002928-7	A15261-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002928-8	A15261-FITC	FITC	100 ug	$570		Add to Cart
BHA21002928-9	A15261-HRP	HRP	100 ug	$570		Add to Cart
BHA21002928-10	A15261-APC	APC	100 ug	$670		Add to Cart
BHA21002928-11	A15261-PE	PE	100 ug	$670		Add to Cart
BHA21002928-12	A15261-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002928-13	A15261-carrier-free	carrier-free	100 ug	$370		Add to Cart

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