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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ITPA Antibody Picoband®

SKU : BHA21005815

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Mfr.No.	A02304, A02304-10ug, A02304-Biotin, A02304-Cy3, A02304-Dylight488, A02304-Dylight550, A02304-Dylight594, A02304-FITC, A02304-HRP, A02304-APC, A02304-PE, A02304-iFluor647, A02304-carrier-free
Alternative Names	Serine/threonine-protein kinase AtPK1/AtPK6
Background	Inosine triphosphate pyrophosphatase is an enzyme that in humans is encoded by the ITPA gene, by the rdgB gene in bacteria E.coli and the HAM1 gene in yeast S. cerevisiae; the protein is also encoded by some RNA viruses of the Potyviridae family. This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alteate splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross reactivity with other proteins.
Description	Boster Bio Anti-ITPA Antibody Picoband® catalog # A02304. Tested in ELISA, IF, IHC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and r
Host	Rabbit
Immunogen Region	E.coli-derived human ITPA recombinant protein (Position: M1-A194). Human ITPA shares 89.6% and 92.1% amino acid (aa) sequence identity with mouse and rat ITPA, respectively.
Isotype	IgG
Molecular Weight	21 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
Tissue Specificity	Expressed in all tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9BY32
Gene Id	3704
Gene Name	ITPA
Subcellular Location	Cytoplasm. Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	ELISA, IF, IHC, WB, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Immunohistochemistry, 2-5 ug/ml, Human, Rat<br> Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Behmanesh, M., Sakumi, K., Abolhassani, N., Toyokuni, S., Oka, S., Ohnishi, Y. N., Tsuchimoto, D., Nakabeppu, Y. ITPase-deficient mice show growth retardation and die before weaning. Cell Death Differ. 16: 1315-1322, 2009.<br /><br />2. Cao, H., Hegele, R. A. DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency. J. Hum. Genet. 47: 620-622, 2002. <br /><br />3. Fellay, J., Thompson, A. J., Ge, D., Gumbs, C. E., Urban, T. J., Shianna, K. V., Little, L. D., Qiu, P., Bertelsen, A. H., Watson, M., Waer, A., Muir, A. J., Brass, C., Albrecht, J., Sulkowski, M., McHutchison, J. G., Goldstein, D. B. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature 464: 405-408, 2010.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005815-1	A02304	-	100 ug	$370		Add to Cart
BHA21005815-2	A02304-10ug	Sample	10 ug	$99		Add to Cart
BHA21005815-3	A02304-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005815-4	A02304-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005815-5	A02304-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005815-6	A02304-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005815-7	A02304-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005815-8	A02304-FITC	FITC	100 ug	$570		Add to Cart
BHA21005815-9	A02304-HRP	HRP	100 ug	$570		Add to Cart
BHA21005815-10	A02304-APC	APC	100 ug	$670		Add to Cart
BHA21005815-11	A02304-PE	PE	100 ug	$670		Add to Cart
BHA21005815-12	A02304-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005815-13	A02304-carrier-free	carrier-free	100 ug	$370		Add to Cart

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