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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IRS1 Antibody Picoband®

SKU : BHA21000110

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Mfr.No.	PB9223, PB9223-10ug, PB9223-Biotin, PB9223-Cy3, PB9223-Dylight488, PB9223-Dylight550, PB9223-Dylight594, PB9223-FITC, PB9223-HRP, PB9223-APC, PB9223-PE, PB9223-iFluor647, PB9223-carrier-free
Alternative Names	Insulin receptor substrate 1
Background	Insulin receptor substrate 1 (IRS-1) is a signalling adapter protein that in humans is encoded by the IRS-1 gene. It is mapped to 2q36.3. This gene exhibited no intrinsic enzyme activity, and it can serve as a docking protein involved in binding and activating other signal transduction molecules after being phosphorylated on tyrosine by insulin receptor kinase. IRS1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to intracellular pathways PI3K/Akt and Erk MAP kinase pathways. IRS1 also has important biological function for both metabolic and mitogenic (growth promoting) pathways. In addition to those, IRS1 is a key regulator of PI3K within malignant cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-IRS1 Antibody Picoband® catalog # PB9223. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosp
Host	Rabbit
Immunogen Region	E.coli-derived human IRS1 recombinant protein (Position: S1041-Q1242). Human IRS1 shares 78% and 80% amino acid (aa) sequences identity with mouse and rat IRS1, respectively.
Isotype	Rabbit IgG
Molecular Weight	132 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Insulin receptor substrate 1;IRS-1;IRS1;
Tissue Specificity	Lymphoid cells.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P35568
Gene Id	3667
Gene Name	IRS1
Sequence	Contains 1 IRS-type PTB domain.
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Western blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, By Heat Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV (December 2006)."Mammary Tumorigenesis and Metastasis Caused by Overexpression of Insulin Receptor Substrate 1 (IRS-1) or IRS-2". Molecular and Cellular Biology 26 (24): 930214. 2. Houghton, A. M., Rzymkiewicz, D. M., Ji, H., Gregory, A. D., Egea, E. E., Metz, H. E., Stolz, D. B., Land, S. R., Marconcini, L. A., Kliment, C. R., Jenkins, K. M., Beaulieu, K. A., Mouded, M., Frank, S. J., Wong, K. K., Shapiro, S. D. Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nature Med. 16: 219-223, 2010. 3. Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., White, M. F. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352: 73-77, 1991.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000110-1	PB9223	100 ug	-	$370		Add to Cart
BHA21000110-2	PB9223-10ug	10 ug	Sample	$99		Add to Cart
BHA21000110-3	PB9223-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000110-4	PB9223-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000110-5	PB9223-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000110-6	PB9223-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000110-7	PB9223-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000110-8	PB9223-FITC	100 ug	FITC	$570		Add to Cart
BHA21000110-9	PB9223-HRP	100 ug	HRP	$570		Add to Cart
BHA21000110-10	PB9223-APC	100 ug	APC	$670		Add to Cart
BHA21000110-11	PB9223-PE	100 ug	PE	$670		Add to Cart
BHA21000110-12	PB9223-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000110-13	PB9223-carrier-free	100 ug	carrier-free	$370		Add to Cart

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