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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IRGM/Irgm1 Antibody Picoband®

SKU : BHA21003584

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Mfr.No.	A33515, A33515-10ug, A33515-Biotin, A33515-Cy3, A33515-Dylight488, A33515-Dylight550, A33515-Dylight594, A33515-FITC, A33515-HRP, A33515-APC, A33515-PE, A33515-iFluor647, A33515-carrier-free
Alternative Names	NADH dehydrogenase 2, mitochondrial
Background	Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enzyme that in humans is IRGM gene. This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alteative splicing results in multiple transcript variants encoding different isoforms.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-IRGM/Irgm1 Antibody Picoband® catalog # A33515. Tested in ELISA, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The
Host	Rabbit
Immunogen Region	E.coli-derived mouse IRGM/Irgm1 recombinant protein (Position: E50-K333).
Isotype	Rabbit IgG
Molecular Weight	45 kDa
Reactivity	Mouse
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	NADH-ubiquinone oxidoreductase chain 2; NADH dehydrogenase subunit 2; Mtnd2; mt-Nd2; Nd2
Tissue Specificity	Ubiquitously expressed.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q60766
Gene Id	15944
Gene Name	Irgm1
Subcellular Location	Mitochondrion inner membrane. Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Mouse ELISA, 0.1-0.5 ug/ml, -

Reference	1. Amre, D. K., Mack, D. R., Morgan, K., Krupoves, A., Costea, I., Lambrette, P., Grimard, G., Dong, J., Feguery, H., Bucionis, V., Deslandres, C., Levy, E., Seidman, E. G. Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children. Inflamm. Bowel Dis. 15: 501-507, 2009. 2. Bekpen, C., Hunn, J. P., Rohde, C., Parvanova, I., Guethlein, L., Dunn, D. M., Glowalla, E., Leptin, M., Howard, J. C. The interferon-inducible p47 (IRG) GTPases in vertebrates: Loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol. 6: R92, 2005. Note: Electronic Article. 3. Brest, P., Lapaquette, P., Souidi, M., Lebrigand, K., Cesaro, A., Vouret-Craviari, V., Mari, B., Barbry, P., Mosnier, J.-F., Hebutee, X., Harel-Bellan, A., Mograbi, B., Darfeuille-Michaud, A., Hofman, P. A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nature Genet. 43: 242-245, 2011.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003584-1	A33515	-	100 ug	$370		Add to Cart
BHA21003584-2	A33515-10ug	Sample	10 ug	$99		Add to Cart
BHA21003584-3	A33515-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003584-4	A33515-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003584-5	A33515-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003584-6	A33515-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003584-7	A33515-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003584-8	A33515-FITC	FITC	100 ug	$570		Add to Cart
BHA21003584-9	A33515-HRP	HRP	100 ug	$570		Add to Cart
BHA21003584-10	A33515-APC	APC	100 ug	$670		Add to Cart
BHA21003584-11	A33515-PE	PE	100 ug	$670		Add to Cart
BHA21003584-12	A33515-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003584-13	A33515-carrier-free	carrier-free	100 ug	$370		Add to Cart

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