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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IRF3 Antibody Picoband®

SKU : BHA21003253

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Mfr.No.	A00165-6, A00165-6-10ug, A00165-6-Biotin, A00165-6-Cy3, A00165-6-Dylight488, A00165-6-Dylight550, A00165-6-Dylight594, A00165-6-FITC, A00165-6-HRP, A00165-6-APC, A00165-6-PE, A00165-6-iFluor647, A00165-6-carrier-free
Alternative Names	interleukin 17C
Background	IRF3 (interferon regulatory factor 3)is a member of the interferon regulatory transcription factor (IRF) family. The IRF3 gene is mapped on 19q13.33. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex withCREBBP. IRF3 plays an important role in theinnate immune system's response toviral infection. AggregatedMAVShave been found to activate IRF3 dimerization. AlthoughIRF3increased transcriptional activity from an ISRE-containing promoter, expression ofIRF3as a Gal4 fusion protein did not activate expression of a chloramphenicol acetyltransferase (CAT) <a href="https://www.bosterbio.com/cells/reporter-cell-lines" style="color:#ea8d28">reporter gene</a> containing repeats of the Gal4-binding sites.Translocation of IRF3 was accompanied by an increase in serine and threonine phosphorylation.The transcriptional activators CREBBP and EP300 coimmunoprecipitated withIRF3only subsequent to viral infection, and the authors stated that these are also subunits of DRAF1.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-IRF3 Antibody Picoband® catalog # A00165-6. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling t
Host	Rabbit
Immunogen Region	E.coli-derived human IRF3 recombinant protein (Position: M1-S427).
Isotype	Rabbit IgG
Molecular Weight	55 kDa
Reactivity	Human, Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Interleukin-17C; Il-17c; Cytokine CX2; Il17c
Tissue Specificity	Expressed by epithelial cells after bacterial challenge. Low expression, if any, in lymphocytes.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	Q14653
Gene Id	3661
Gene Name	IRF3
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Bellingham, J., Gregory-Evans, K., Gregory-Evans, C. Y. Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker. Ann. Hum. Genet. 62: 231-234, 1998.<br /><br />2. Doyle, S. E., Vaidya, S. A., O'Connell, R., Dadgostar, H., Dempsey, P. W., Wu, T.-T., Rao, G., Sun, R., Haberland, M. E., Modlin, R. L., Cheng, G.IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity 17: 251-263, 2002.<br /><br />3. Stetson, D. B., Medzhitov, R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24: 93-103, 2006.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003253-1	A00165-6	-	100 ug	$370		Add to Cart
BHA21003253-2	A00165-6-10ug	Sample	10 ug	$99		Add to Cart
BHA21003253-3	A00165-6-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003253-4	A00165-6-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003253-5	A00165-6-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003253-6	A00165-6-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003253-7	A00165-6-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003253-8	A00165-6-FITC	FITC	100 ug	$570		Add to Cart
BHA21003253-9	A00165-6-HRP	HRP	100 ug	$570		Add to Cart
BHA21003253-10	A00165-6-APC	APC	100 ug	$670		Add to Cart
BHA21003253-11	A00165-6-PE	PE	100 ug	$670		Add to Cart
BHA21003253-12	A00165-6-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003253-13	A00165-6-carrier-free	carrier-free	100 ug	$370		Add to Cart

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