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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IRAK2 Antibody Picoband®

SKU : BHA21002469

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Mfr.No.	A01559, A01559-10ug, A01559-Biotin, A01559-Cy3, A01559-Dylight488, A01559-Dylight550, A01559-Dylight594, A01559-FITC, A01559-HRP, A01559-APC, A01559-PE, A01559-iFluor647, A01559-carrier-free
Alternative Names	interleukin-1 receptor-associated kinase 2
Background	Interleukin-1 receptor-associated kinase-like 2 is an enzyme that in humans is encoded by the IRAK2 gene. This gene is mapped to 3p25.3. IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. It binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-IRAK2 Antibody Picoband® catalog # A01559. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human IRAK2, which shares 64.7% and 67.6% amino acid (aa) sequence identity with mouse and rat IRAK2, respectively.
Isotype	Rabbit IgG
Molecular Weight	69 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Interleukin-1 receptor-associated kinase-like 2; IRAK-2; IRAK2
Tissue Specificity	Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	O43187
Gene Id	3656
Gene Name	IRAK2
Subcellular Location	Cytosol. Endosome membrane. Nucleus. Plasma Membrane. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.25ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Rat<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Conner, J. R., Smiova, I. I., Poltorak, A. A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice. J. Exp. Med. 206: 1615-1631, 2009.<br /><br />2. Lin, S.-C., Lo, Y.-C., Wu, H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 465: 885-890, 2010.<br /><br />3. Muzio, M., Ni, J., Feng, P., Dixit, V. M. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278: 1612-1615, 1997.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002469-1	A01559	-	100 ug	$370		Add to Cart
BHA21002469-2	A01559-10ug	Sample	10 ug	$99		Add to Cart
BHA21002469-3	A01559-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002469-4	A01559-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002469-5	A01559-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002469-6	A01559-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002469-7	A01559-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002469-8	A01559-FITC	FITC	100 ug	$570		Add to Cart
BHA21002469-9	A01559-HRP	HRP	100 ug	$570		Add to Cart
BHA21002469-10	A01559-APC	APC	100 ug	$670		Add to Cart
BHA21002469-11	A01559-PE	PE	100 ug	$670		Add to Cart
BHA21002469-12	A01559-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002469-13	A01559-carrier-free	carrier-free	100 ug	$370		Add to Cart

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