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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IRAK/IRAK1 Antibody Picoband®

SKU : BHA21007380

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Mfr.No.	PA2183, PA2183-10ug, PA2183-Biotin, PA2183-Cy3, PA2183-Dylight488, PA2183-Dylight550, PA2183-Dylight594, PA2183-FITC, PA2183-HRP, PA2183-APC, PA2183-PE, PA2183-iFluor647, PA2183-carrier-free
Alternative Names	Interleukin-1 receptor-associated kinase 1
Background	Interleukin-1 receptor-associated kinase 1, also called IRAK1, is an enzyme that in humans is encoded by the IRAK1 gene. By radiation hybrid analysis, this gene is mapped to chromosome Xq28. Serine/threonine-protein kinase plays a critical role in initiating innate immune response against foreign pathogens. This gene involved in Toll-like receptor (TLR) and IL-1R signaling pathways. This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-IRAK/IRAK1 Antibody catalog # PA2183. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human IRAK, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	274 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Interleukin-1 receptor-associated kinase 1;IRAK-1;2.7.11.1;IRAK1;IRAK;
Tissue Specificity	Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P51617
Gene Name	IRAK1
Sequence	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Subcellular Location	Cytoplasm . Nucleus . Lipid droplet . Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Western blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Chassin, C., Kocur, M., Pott, J., Duerr, C. U., Gutle, D., Lotz, M., Hornef, M. W. miR-146a mediates protective innate immune tolerance in the neonate intestine. Cell Host Microbe 8: 358-368, 2010. <br /><br />2. Jacob, C. O., Zhu, J., Armstrong, D. L., Yan, M., Han, J., Zhou, X. J., Thomas, J. A., Reiff, A., Myones, B. L., Ojwang, J. O., Kaufman, K. M., Klein-Gitelman, M., and 17 others. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc. Nat. Acad. Sci. 106: 6256-6261, 2009.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007380-1	PA2183	-	100 ug	$370		Add to Cart
BHA21007380-2	PA2183-10ug	Sample	10 ug	$99		Add to Cart
BHA21007380-3	PA2183-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007380-4	PA2183-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007380-5	PA2183-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007380-6	PA2183-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007380-7	PA2183-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007380-8	PA2183-FITC	FITC	100 ug	$570		Add to Cart
BHA21007380-9	PA2183-HRP	HRP	100 ug	$570		Add to Cart
BHA21007380-10	PA2183-APC	APC	100 ug	$670		Add to Cart
BHA21007380-11	PA2183-PE	PE	100 ug	$670		Add to Cart
BHA21007380-12	PA2183-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007380-13	PA2183-carrier-free	carrier-free	100 ug	$370		Add to Cart

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