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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Ionotropic Glutamate receptor 2/GRIA2 Antibody Picoband®

SKU : BHA21000129

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Mfr.No.	PB9205, PB9205-10ug, PB9205-Biotin, PB9205-Cy3, PB9205-Dylight488, PB9205-Dylight550, PB9205-Dylight594, PB9205-FITC, PB9205-HRP, PB9205-APC, PB9205-PE, PB9205-iFluor647, PB9205-carrier-free
Alternative Names	Glutamate receptor 2
Background	Glutamate receptor 2, also known as GLUR2, is a protein that in humans is encoded by the GRIA2 gene. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. GLUR2's cytogenetic location is 4q32.1. The crystal structures of the GLUR2 ligand-binding core in the apo state and in the presence of the antagonist DNQX, the partial agonist kainate, and the full agonists AMPA and glutamate.GLUR2 plays a major role in depression at synapses in which glutamate remains in the synaptic cleft for prolonged periods of time during normal operation of the synapse. The overexpression of GLUR2 increases dendritic spine size and density in hippocampal neurons, and more remarkably, induces spine formation in GABA-releasing inteeurons that normally lack spines.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Ionotropic Glutamate receptor 2/GRIA2 Antibody Picoband® catalog # PB9205. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous sys
Host	Rabbit
Immunogen Region	E.coli-derived human GRIA2 recombinant protein (Position: N25-I360). Human GRIA2 shares 99% amino acid (aa) sequence identity with both mouse and rat GRIA2.
Isotype	Rabbit IgG
Molecular Weight	110 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Glutamate receptor 2;GluR-2;AMPA-selective glutamate receptor 2;GluR-B;GluR-K2;Glutamate receptor ionotropic, AMPA 2;GluA2;GRIA2;GLUR2;
Tissue Specificity	Widely expressed in brain.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P42262
Gene Id	14800
Gene Name	GRIA2
Subcellular Location	Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, IHC-F, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, Human, By Heat Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Rat Immunocytochemistry, 0.5-1ug/ml, Human Immunofluorescence, 2ug/ml, Mouse Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Armstrong, N., Gouaux, E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron 28: 165-181, 2000. 2. Biou, V., Bhattacharyya, S., Malenka, R. C. Endocytosis and recycling of AMPA receptors lacking GluR2/3. Proc. Nat. Acad. Sci. 105: 1038-1043, 2008. 3. Mameli, M., Balland, B., Lujan, R., Luscher, C. Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science 317: 530-533, 2007.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000129-1	PB9205	100 ug	-	$370		Add to Cart
BHA21000129-2	PB9205-10ug	10 ug	Sample	$99		Add to Cart
BHA21000129-3	PB9205-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000129-4	PB9205-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000129-5	PB9205-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000129-6	PB9205-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000129-7	PB9205-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000129-8	PB9205-FITC	100 ug	FITC	$570		Add to Cart
BHA21000129-9	PB9205-HRP	100 ug	HRP	$570		Add to Cart
BHA21000129-10	PB9205-APC	100 ug	APC	$670		Add to Cart
BHA21000129-11	PB9205-PE	100 ug	PE	$670		Add to Cart
BHA21000129-12	PB9205-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000129-13	PB9205-carrier-free	100 ug	carrier-free	$370		Add to Cart

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