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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Interleukin-18 IL18 Antibody Picoband®

SKU : BHA21006592

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Mfr.No.	RP1017, RP1017-10ug, RP1017-Biotin, RP1017-Cy3, RP1017-Dylight488, RP1017-Dylight550, RP1017-Dylight594, RP1017-FITC, RP1017-HRP, RP1017-APC, RP1017-PE, RP1017-iFluor647, RP1017-carrier-free
Alternative Names	Interleukin-18
Background	Interleukin-18 also known as IL18 is a protein which in humans is encoded by the IL18 gene. The protein encoded by this gene is a proinflammatory cytokine.IL-18 is a cytokine produced by macrophages and other cells that belongs to the IL-1 superfamily. IL-18 works by binding to the interleukin-18 receptor, and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide (LPS). After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-gamma (IFN-gamma) or type II interferon that plays an important role in activating the macrophages or other cells.The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio <a href="https://www.bosterbio.com/anti-il-18-antibody-pa1342-boster.html" style="color:#EA8D28">Anti-Interleukin-18 IL18 Antibody</a> catalog # RP1017. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
Host	Rabbit
Immunogen Region	E. coli-derived mouse IL-18 recombinant protein (Position: N36-S192).
Isotype	Rabbit IgG
Molecular Weight	22 kDa
Reactivity	Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Interleukin-18;IL-18;Interferon gamma-inducing factor;IFN-gamma-inducing factor;Interleukin-1 gamma;IL-1 gamma;Il18;Igif;
Tissue Specificity	Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P70380
Gene Name	IL18
Sequence	Belongs to the IL-10 family.
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Mouse, By Heat<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K (November 1995). "Cloning of a new cytokine that induces IFN-gamma production by T cells". Nature 378 (6552): 8891.<br /><br />2. Nolan KF, Greaves DR, Waldmann H (July 1998). "The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci". Genomics 51 (1): 1613.. <br /><br />3. "Entrez Gene: IL18 interleukin 18 (interferon-gamma-inducing factor)". <br /><br />4. Nolan, K. F., Greaves, D. R., Waldmann, H. The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci. Genomics 51: 161-163, 1998.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006592-1	RP1017	-	100 ug	$370		Add to Cart
BHA21006592-2	RP1017-10ug	Sample	10 ug	$99		Add to Cart
BHA21006592-3	RP1017-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006592-4	RP1017-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006592-5	RP1017-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006592-6	RP1017-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006592-7	RP1017-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006592-8	RP1017-FITC	FITC	100 ug	$570		Add to Cart
BHA21006592-9	RP1017-HRP	HRP	100 ug	$570		Add to Cart
BHA21006592-10	RP1017-APC	APC	100 ug	$670		Add to Cart
BHA21006592-11	RP1017-PE	PE	100 ug	$670		Add to Cart
BHA21006592-12	RP1017-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006592-13	RP1017-carrier-free	carrier-free	100 ug	$370		Add to Cart

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