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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Interferon regulatory factor 3 IRF3 Antibody Picoband®

SKU : BHA21007086

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Mfr.No.	PA1819, PA1819-10ug, PA1819-Biotin, PA1819-Cy3, PA1819-Dylight488, PA1819-Dylight550, PA1819-Dylight594, PA1819-FITC, PA1819-HRP, PA1819-APC, PA1819-PE, PA1819-iFluor647, PA1819-carrier-free
Alternative Names	Interferon regulatory factor 3
Background	IRF3 (interferon regulatory factor 3) is a member of the interferon regulatory transcription factor (IRF) family. The IRF3 gene is mapped on 19q13.33. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. IRF3 plays an important role in the innate immune system's response to viral infection. Aggregated MAVS have been found to activate IRF3 dimerization. Although IRF3 increased transcriptional activity from an ISRE-containing promoter, expression of IRF3 as a Gal4 fusion protein did not activate expression of a chloramphenicol acetyltransferase (CAT) reporter gene containing repeats of the Gal4-binding sites. Translocation of IRF3 was accompanied by an increase in serine and threonine phosphorylation. The transcriptional activators CREBBP and EP300 coimmunoprecipitated with IRF3 only subsequent to viral infection, and the authors stated that these are also subunits of DRAF1.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Interferon regulatory factor 3 IRF3 Antibody catalog # PA1819. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-sti
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human IRF3, different from the related mouse and rat sequences by five amino acids.
Isotype	Rabbit IgG
Molecular Weight	55 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Interferon regulatory factor 3;IRF-3;IRF3;
Tissue Specificity	Expressed constitutively in a variety of tissues.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	Q14653
Gene Name	IRF3
Sequence	Belongs to the IRF family.
Subcellular Location	Cytoplasm . Nucleus . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Bellingham, J., Gregory-Evans, K., Gregory-Evans, C. Y. Mapping of human interferon regulatory factor 3 (IRF3) to chromosome 19q13.3-13.4 by an intragenic polymorphic marker. Ann. Hum. Genet. 62: 231-234, 1998.<br /><br />2. Doyle, S. E., Vaidya, S. A., O'Connell, R., Dadgostar, H., Dempsey, P. W., Wu, T.-T., Rao, G., Sun, R., Haberland, M. E., Modlin, R. L., Cheng, G.IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity 17: 251-263, 2002.<br /><br />3. Stetson, D. B., Medzhitov, R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24: 93-103, 2006.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007086-1	PA1819	-	100 ug	$370		Add to Cart
BHA21007086-2	PA1819-10ug	Sample	10 ug	$99		Add to Cart
BHA21007086-3	PA1819-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007086-4	PA1819-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007086-5	PA1819-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007086-6	PA1819-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007086-7	PA1819-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007086-8	PA1819-FITC	FITC	100 ug	$570		Add to Cart
BHA21007086-9	PA1819-HRP	HRP	100 ug	$570		Add to Cart
BHA21007086-10	PA1819-APC	APC	100 ug	$670		Add to Cart
BHA21007086-11	PA1819-PE	PE	100 ug	$670		Add to Cart
BHA21007086-12	PA1819-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007086-13	PA1819-carrier-free	carrier-free	100 ug	$370		Add to Cart

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