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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Integrin alpha 3/ITGA3 Antibody Picoband®

SKU : BHA21006934

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Mfr.No.	PA1621, PA1621-10ug, PA1621-Biotin, PA1621-Cy3, PA1621-Dylight488, PA1621-Dylight550, PA1621-Dylight594, PA1621-FITC, PA1621-HRP, PA1621-APC, PA1621-PE, PA1621-iFluor647, PA1621-carrier-free
Alternative Names	Integrin alpha-3
Background	ITGA3 (INTEGRIN, ALPHA-3), also called CD49C, VLA3 or GAPB3, is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit which is also a member of the family of cell surface adhesion molecules. ITGA3 is mapped to chromosome 17 and its exact cytogenetic location is 17q21.33. ITGA3 makes up half of the alpha3beta1 integrin duplex that plays a role in neural migration and corticogenesis together with beta-1 subunit. A functional link between DAB1 phosphorylation and ITGA3 signaling drives the timely detachment of migrating neurons from radial glial fibers. Expression of human ITGA3 increased the infectivity of virus for Chinese hamster ovary cells. ITGA3 also contains 13 potential N-glycosylation sites, 2 potential cleavage sites, and the 7 N-terminal repeating units characteristic of ITGAs. Recombinant ITGA3 is expressed as a 150-kD protein as the same size as the native protein by the weste blot analysis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Integrin alpha 3/ITGA3 Antibody catalog # PA1621. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may p
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Integrin alpha 3, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	155 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Integrin alpha-3;CD49 antigen-like family member C;FRP-2;Galactoprotein B3;GAPB3;VLA-3 subunit alpha;CD49c;Integrin alpha-3 heavy chain;Integrin alpha-3 light chain;ITGA3;MSK18;
Tissue Specificity	Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P26006
Gene Name	ITGA3
Sequence	Belongs to the integrin alpha chain family.
Subcellular Location	Cell membrane ; Single-pass type I membrane protein . Cell membrane ; Lipid-anchor . Cell projection, invadopodium membrane ; Single-pass type I membrane protein . Cell projection, filopodium membrane ; Single-pass type I membrane protein . Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, IHC, ICC, WB, Flow Cytometry
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry(Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Akula, S. M., Pramod, N. P., Wang, F.-Z., Chandran, B. Integrin alpha-3/beta-1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells. Cell 108: 407-419, 2002. <br /><br />2. Dulabon, L., Olson, E. C., Taglienti, M. G., Eisenhuth, S., McGrath, B., Walsh, C. A., Kreidberg, J. A., Anton, E. S. Reelin binds alpha-3-beta-1 integrin and inhibits neuronal migration. Neuron 27: 33-44, 2000. <br /><br />3. Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME (Oct 1991). "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen". <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006934-1	PA1621	-	100 ug	$370		Add to Cart
BHA21006934-2	PA1621-10ug	Sample	10 ug	$99		Add to Cart
BHA21006934-3	PA1621-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006934-4	PA1621-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006934-5	PA1621-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006934-6	PA1621-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006934-7	PA1621-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006934-8	PA1621-FITC	FITC	100 ug	$570		Add to Cart
BHA21006934-9	PA1621-HRP	HRP	100 ug	$570		Add to Cart
BHA21006934-10	PA1621-APC	APC	100 ug	$670		Add to Cart
BHA21006934-11	PA1621-PE	PE	100 ug	$670		Add to Cart
BHA21006934-12	PA1621-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006934-13	PA1621-carrier-free	carrier-free	100 ug	$370		Add to Cart

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