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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Integrin alpha 3/ITGA3 Antibody Picoband®

SKU : BHA21004131

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Mfr.No.	A02902-1, A02902-1-10ug, A02902-1-Biotin, A02902-1-Cy3, A02902-1-Dylight488, A02902-1-Dylight550, A02902-1-Dylight594, A02902-1-FITC, A02902-1-HRP, A02902-1-APC, A02902-1-PE, A02902-1-iFluor647, A02902-1-carrier-free
Alternative Names	integrin subunit alpha 3
Background	ITGA3(INTEGRIN, ALPHA-3), also called CD49C, VLA3 or GAPB3, is a protein that in humans is encoded by the ITGA3 gene. It is an integrin alpha subunit which is also a member of the family of cell surface adhesion molecules. This gene is mapped to chromosome 17 and its exact cytogenetic location is 17q21.33. ITGA3 makes up half of the alpha3beta1 integrin duplex that plays a role in neural migration and corticogenesis together with beta-1 subunit.A functional link between DAB1 phosphorylation and ITGA3 signaling drives the timely detachment of migrating neurons from radial glial fibers. Expression of human ITGA3 increased the infectivity of virus for Chinese hamster ovary cells. ITGA3 also contains 13 potential N-glycosylation sites, 2 potential cleavage sites, and the 7 N-terminal repeating units characteristic of ITGAs. Recombinant ITGA3 is expressed as a 150-kD protein as the same size as the native protein by the weste blot analysis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Integrin alpha 3/ITGA3 Antibody Picoband® catalog # A02902-1. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may p
Host	Rabbit
Immunogen Region	E.coli-derived human Integrin alpha 3/ITGA3 recombinant protein (Position: L96-L324).
Isotype	Rabbit IgG
Molecular Weight	130 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Integrin alpha-3; CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD49c; Integrin alpha-3 heavy chain; Integrin alpha-3 light chain; ITGA3; MSK18
Tissue Specificity	Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P26006
Gene Id	3675
Gene Name	ITGA3
Subcellular Location	Cell membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, IF, IHC, ICC, WB, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry(Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Akula, S. M., Pramod, N. P., Wang, F.-Z., Chandran, B. Integrin alpha-3/beta-1 (CD 49c/29) is a cellular receptor for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) entry into the target cells. Cell 108: 407-419, 2002. <br /><br />2. Dulabon, L., Olson, E. C., Taglienti, M. G., Eisenhuth, S., McGrath, B., Walsh, C. A., Kreidberg, J. A., Anton, E. S. Reelin binds alpha-3-beta-1 integrin and inhibits neuronal migration. Neuron 27: 33-44, 2000. <br /><br />3. Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME (Oct 1991). "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen".

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004131-1	A02902-1	-	100 ug	$370		Add to Cart
BHA21004131-2	A02902-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21004131-3	A02902-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004131-4	A02902-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004131-5	A02902-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004131-6	A02902-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004131-7	A02902-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004131-8	A02902-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21004131-9	A02902-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21004131-10	A02902-1-APC	APC	100 ug	$670		Add to Cart
BHA21004131-11	A02902-1-PE	PE	100 ug	$670		Add to Cart
BHA21004131-12	A02902-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004131-13	A02902-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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