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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Integrin alpha 1/ITGA1 Antibody Picoband®

SKU : BHA21006633

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Mfr.No.	PA1045-1, PA1045-1-10ug, PA1045-1-Biotin, PA1045-1-Cy3, PA1045-1-Dylight488, PA1045-1-Dylight550, PA1045-1-Dylight594, PA1045-1-FITC, PA1045-1-HRP, PA1045-1-APC, PA1045-1-PE, PA1045-1-iFluor647, PA1045-1-carrier-free
Alternative Names	Integrin alpha-1
Background	Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Integrin alpha 1/ITGA1 Antibody catalog # PA1045-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha 1, different from the related mouse and rat sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	190-200 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Integrin alpha-1;CD49 antigen-like family member A;Laminin and collagen receptor;VLA-1;CD49a;ITGA1;
Tissue Specificity	Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. .
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P56199
Gene Name	ITGA1
Sequence	Belongs to the integrin alpha chain family.
Subcellular Location	Membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Rat, Mouse, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Douville, P.; Seldin, M. F.; Carbonetto, S. : Genetic mapping of the integrin alpha-1 gene (Vla1) to mouse chromosome 13. Genomics 14: 503-505, 1992.<br /><br />2. Lee HJ, Kim SY; Koh JM; Bok J; Kim KJ; Kim KS; Park MH; Shin HD; Park BL; Kim TH; Hong JM; Park EK; Kim DJ; Oh B; Kimm K; Kim GS; Lee JY. Polymorphisms and haplotypes of integrinalpha1 (ITGA1) are associated with bone mineral absorbance and fracture risk in postmenopausal Koreans.Bone. 2007 Dec;41(6):979-86. Epub 2007 Sep 5.<br /><br />3. Ekholm, E.; Hankenson, K. D.; Uusitalo, H.; Hiltunen, A.; Gardner, H.; Heino, J.; Penttinen, R. : Diminished callus size and cartilage synthesis in alpha-1 beta-1 integrin-deficient mice during bone fracture healing. Am. J. Path. 160: 1779-1785, 2002.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006633-1	PA1045-1	-	100 ug	$370		Add to Cart
BHA21006633-2	PA1045-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21006633-3	PA1045-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006633-4	PA1045-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006633-5	PA1045-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006633-6	PA1045-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006633-7	PA1045-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006633-8	PA1045-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21006633-9	PA1045-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21006633-10	PA1045-1-APC	APC	100 ug	$670		Add to Cart
BHA21006633-11	PA1045-1-PE	PE	100 ug	$670		Add to Cart
BHA21006633-12	PA1045-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006633-13	PA1045-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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