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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Insulin Receptor/INSR Antibody Picoband®

SKU : BHA21006933

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Mfr.No.	PA1620, PA1620-10ug, PA1620-Biotin, PA1620-Cy3, PA1620-Dylight488, PA1620-Dylight550, PA1620-Dylight594, PA1620-FITC, PA1620-HRP, PA1620-APC, PA1620-PE, PA1620-iFluor647, PA1620-carrier-free
Alternative Names	Insulin receptor
Background	INSR (INSULIN RECEPTOR) is a tetramer of 2 alpha and 2 beta subunits that are coded by a single gene and are joined by disulfide bonds, a mechanism parallel to that of its ligand, insulin. It belongs to the large class of tyrosine kinase receptors. The insulin receptor gene is mapped to 19p13.2. The insulin receptor mediates their activity by causing the addition of a phosphate group to particular tyrosines on certain proteins within a cell. The INSR gene spans more than 120 kb and has 22 exons. Functional studies of the INSR SNPs show no effect on mRNA levels or splicing in peripheral blood leukocytes or on binding of insulin to mononuclear cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Insulin Receptor/INSR Antibody catalog # PA1620. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling interme
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Insulin Receptor, different from the related rat and mouse sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	155 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Insulin receptor;IR;2.7.10.1;CD220;Insulin receptor subunit alpha;Insulin receptor subunit beta;INSR;
Tissue Specificity	Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P06213
Gene Name	INSR
Sequence	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. 't Hart, L. M., Stolk, R. P., Dekker, J. M., Nijpels, G., Grobbee, D. E., Heine, R. J., Maassen, J. A. Prevalence of variants in candidate genes for type 2 diabetes mellitus in the Netherlands: the Rotterdam study and the Hoo study. J. Clin. Endocr. Metab. 84: 1002-1006, 1999. <br /><br />2. Accili, D., Drago, J., Lee, E. J., Johnson, M. D., Cool, M. H., Salvatore, P., Asico, L. D., Jose, P. A., Taylor, S. I., Westphal, H. Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nature Genet. 12: 106-109, 1996. <br /><br />3. Ward CW, Lawrence MC (April 2009). "Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor". <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006933-1	PA1620	-	100 ug	$370		Add to Cart
BHA21006933-2	PA1620-10ug	Sample	10 ug	$99		Add to Cart
BHA21006933-3	PA1620-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006933-4	PA1620-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006933-5	PA1620-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006933-6	PA1620-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006933-7	PA1620-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006933-8	PA1620-FITC	FITC	100 ug	$570		Add to Cart
BHA21006933-9	PA1620-HRP	HRP	100 ug	$570		Add to Cart
BHA21006933-10	PA1620-APC	APC	100 ug	$670		Add to Cart
BHA21006933-11	PA1620-PE	PE	100 ug	$670		Add to Cart
BHA21006933-12	PA1620-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006933-13	PA1620-carrier-free	carrier-free	100 ug	$370		Add to Cart

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