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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Indoleamine 2, 3-dioxygenase/IDO1 Antibody Picoband®

SKU : BHA21000499

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Mfr.No.	PB9603, PB9603-10ug, PB9603-Biotin, PB9603-Cy3, PB9603-Dylight488, PB9603-Dylight550, PB9603-Dylight594, PB9603-FITC, PB9603-HRP, PB9603-APC, PB9603-PE, PB9603-iFluor647, PB9603-carrier-free
Alternative Names	Indoleamine 2,3-dioxygenase 1
Background	IDO1 (INDOLEAMINE 2,3-DIOXYGENASE), INDO or IDO, is an immunomodulatory enzyme produced by some alteatively activated macrophages and other immunoregulatory cells. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine. By fluorescence in situ hybridization, the assignment is narrowed to chromosome 8p12-p11. INDO Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase. During inflammation, IDO is upregulated in dendritic cells and phagocytes by proinflammatory stimuli, most notably IFNG, and the enzyme then uses superoxide as a 'cofactor' for oxidative cleavage of the indole ring of tryptophan, yielding an intermediate that deformylates to L-kynurenine.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Indoleamine 2, 3-dioxygenase/IDO1 Antibody Picoband® catalog # PB9603. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human IDO1, different from the related mouse sequence by fourteen amino acids, and from the related rat sequence by seventeen amino acids.
Isotype	Rabbit IgG
Molecular Weight	45 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Indoleamine 2,3-dioxygenase 1;IDO-1;1.13.11.52;Indoleamine-pyrrole 2,3-dioxygenase;IDO1;IDO, INDO;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P14902
Gene Id	3620
Gene Name	IDO1
Sequence	Belongs to the indoleamine 2,3-dioxygenase family.
Subcellular Location	Mitochondrion.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. Burkin, D. J., Kimbro, K. S., Barr, B. L., Jones, C., Taylor, M. W., Gupta, S. L. Localization of the human indoleamine 2,3-dioxygenase (IDO) gene to the pericentromeric region of human chromosome 8. Genomics 17: 262-263, 1993. 2. Dai, W., Gupta, S. L. Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA. Biochem. Biophys. Res. Commun. 168: 1-8, 1990. 3. Fallarino, F., Grohmann, U., Hwang, K. W., Orabona, C., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Alegre, M.-L., Puccetti, P. Modulation of tryptophan catabolism by regulatory T cells. Nature Immun. 4: 1206-1212, 2003.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000499-1	PB9603	100 ug	-	$370		Add to Cart
BHA21000499-2	PB9603-10ug	10 ug	Sample	$99		Add to Cart
BHA21000499-3	PB9603-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000499-4	PB9603-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000499-5	PB9603-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000499-6	PB9603-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000499-7	PB9603-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000499-8	PB9603-FITC	100 ug	FITC	$570		Add to Cart
BHA21000499-9	PB9603-HRP	100 ug	HRP	$570		Add to Cart
BHA21000499-10	PB9603-APC	100 ug	APC	$670		Add to Cart
BHA21000499-11	PB9603-PE	100 ug	PE	$670		Add to Cart
BHA21000499-12	PB9603-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000499-13	PB9603-carrier-free	100 ug	carrier-free	$370		Add to Cart

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