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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Il2ra Antibody

SKU : BHA21004242

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Mfr.No.	A00214-2, A00214-2-10ug, A00214-2-Biotin, A00214-2-Cy3, A00214-2-Dylight488, A00214-2-Dylight550, A00214-2-Dylight594, A00214-2-FITC, A00214-2-HRP, A00214-2-APC, A00214-2-PE, A00214-2-iFluor647, A00214-2-carrier-free
Alternative Names	GTP-binding nuclear protein Ran
Background	IL2RA(Interleukin 2 receptor, alpha), also called IL2R, IL2R, Alpha Chain or CD25, is a protein that in humans is encoded by the IL2RA gene.The IL2RA gene is mapped on 10p15.1. IL2RA is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL2RA uses a composite surface to dock into a groove on IL2 that also serves as a binding site for antagonist drugs.Homodimeric alpha chains(IL2RA) result in low-affinity receptor, while homodimeric beta(IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Infection by the protozoan Trypanosoma cruzi causes Chagas disease, characterized by a reduction in the amount of IL2RA expressed on the surface of immune cells. This leads to chronic immune suppression, becoming increasingly severe over the course of many years and ultimately resulting in death if left untreated.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Il2ra Antibody Picoband® catalog # A00214-2. Tested in ELISA, IF, IHC, ICC applications. This antibody reacts with Mouse, Rat.
Function	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays
Host	Rabbit
Immunogen Region	E.coli-derived mouse Il2ra recombinant protein (Position: E22-I268).
Isotype	Rabbit IgG
Molecular Weight	50 kDa
Reactivity	Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	GTP-binding nuclear protein Ran;Androgen receptor-associated protein 24;GTPase Ran;Ras-like protein TC4;Ras-related nuclear protein;RAN;ARA24;OK/SW-cl.81;
Tissue Specificity	Expressed in a variety of tissues. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P01590
Gene Id	16184
Gene Name	Il2ra
Subcellular Location	Nucleus. Cytoplasm. Melanosome. Nucleus envelope . Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis. Colocalizes with NEMP1 at the nuclear envelope (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	IHC, ICC, IF, ELISA
Description	Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Mouse<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Ansano, M., Toda, M., Sakaguchi, N., Sakaguchi, S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184: 387-396, 1996.<br /><br />2. Cosman, D., Cerretti, D. P., Larsen, A., Park, L., March, C., Dower, S., Gillis, S., Urdal, D. Cloning, sequence and expression of human interleukin-2 receptor. Nature 312: 768-771, 1984.<br /><br />3. Hori, S., Nomura, T., Sakaguchi, S. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061, 2003.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004242-1	A00214-2	-	100 ug	$370		Add to Cart
BHA21004242-2	A00214-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004242-3	A00214-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004242-4	A00214-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004242-5	A00214-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004242-6	A00214-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004242-7	A00214-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004242-8	A00214-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004242-9	A00214-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004242-10	A00214-2-APC	APC	100 ug	$670		Add to Cart
BHA21004242-11	A00214-2-PE	PE	100 ug	$670		Add to Cart
BHA21004242-12	A00214-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004242-13	A00214-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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