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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IL2 Receptor gamma/IL2RG Antibody Picoband®

SKU : BHA21002926

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Mfr.No.	A00308-1, A00308-1-10ug, A00308-1-Biotin, A00308-1-Cy3, A00308-1-Dylight488, A00308-1-Dylight550, A00308-1-Dylight594, A00308-1-FITC, A00308-1-HRP, A00308-1-APC, A00308-1-PE, A00308-1-iFluor647, A00308-1-carrier-free
Alternative Names	Interferon alpha/beta receptor 1
Background	IL2RG (INTERLEUKIN 2 RECEPTOR, GAMMA),also known as Common gamma chain or CD132, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors:IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. IL2RG is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. By fluorescence in situ hybridization and PCR amplification of somatic cell hybrid DNAs, The IL2RG gene is mapped to Xq13.1. The IL2RG gene contains 8 exons and spans approximately 4.2 kb. And the gamma chain is an indispensable component of the functional IL2 receptor. Lymphocytes expressing the common gamma chain can form functional receptors for these cytokine proteins, which transmit signals from one cell to another and programs of cellular differentiation. The sharing of the gamma subunit by several receptors explains why humans and mice that lack IL2 entirely show milder symptoms than those with IL2RG deficiency.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-IL2 Receptor gamma/IL2RG Antibody Picoband® catalog # A00308-1. Tested in IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:76
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human IL2 Receptor gamma/IL2RG, which shares 78.9% amino acid (aa) sequence identity with both mouse and rat IL2 Receptor gamma/IL2RG.
Isotype	Rabbit IgG
Molecular Weight	65 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Interferon alpha/beta receptor 1;IFN-R-1;IFN-alpha/beta receptor 1;Cytokine receptor class-II member 1;Cytokine receptor family 2 member 1;CRF2-1;Type I interferon receptor 1;IFNAR1;IFNAR;
Tissue Specificity	IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. .
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P31785
Gene Id	3561
Gene Name	IL2RG
Subcellular Location	Isoform 1: Cell membrane ; Single- pass type I membrane protein . Late endosome . Lysosome . Interferon binding triggers intealization of the receptor from the cell membrane into endosomes and then into lysosomes. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, ICC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br>

Reference	1. Asao, H., Okuyama, C., Kumaki, S., Ishii, N., Tsuchiya, S., Foster, D., Sugamura, K. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J. Immun. 167: 1-5, 2001.<br /><br />2. Brandt, K., Singh, P. B., Bulfone-Paus, S., Ruckert, R. Interleukin-21: a new modulator of immunity, infection, and cancer. Cytokine Growth Factor Rev. 18: 223-232, 2007.<br /><br />3. PDB 2B5IWang X, Rickert M, Garcia KC (November 2005). "Structure of the quateary complex of interleukin-2 with its alpha, beta, and gammac receptors". Science 310 (5751): 115963. doi:10.1126/science.1117893. PMID 16293754. <br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002926-1	A00308-1	-	100 ug	$370		Add to Cart
BHA21002926-2	A00308-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002926-3	A00308-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002926-4	A00308-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002926-5	A00308-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002926-6	A00308-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002926-7	A00308-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002926-8	A00308-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002926-9	A00308-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002926-10	A00308-1-APC	APC	100 ug	$670		Add to Cart
BHA21002926-11	A00308-1-PE	PE	100 ug	$670		Add to Cart
BHA21002926-12	A00308-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002926-13	A00308-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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