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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IL1 beta/IL1B Antibody

SKU : BHA21000502

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Mfr.No.	PB9606, PB9606-10ug, PB9606-Biotin, PB9606-Cy3, PB9606-Dylight488, PB9606-Dylight550, PB9606-Dylight594, PB9606-FITC, PB9606-HRP, PB9606-APC, PB9606-PE, PB9606-iFluor647, PB9606-carrier-free
Alternative Names	Interleukin-1 beta
Background	Interleukin-1beta (IL-1beta) is a potent stimulator of bone resorption whose gene is mapped to 2q14, and has been implicated in the pathogenesis of high bone tuover and osteoporosis. IL-1beta, a prominent microglia-derived cytokine, caused oligodendrocyte death in coculture with astrocytes and microglia, but not in pure culture of oligodendrocytes alone. It also can cause nuclear export of a specific NCOR corepressor complex, resulting in derepression of a specific subset of nuclear factor-kappa-B (NFKB)-regulated genes. Furthermore, Microenvironmental IL-1beta and, to a lesser extent, IL-1alpha are required for in vivo angiogenesis and invasiveness of different tumor cells. Additional, the cooperation of IL-1beta and PDGFB induces contractile-to-synthetic phenotype modulation of human aortic smooth muscle cells in culture. Moreover, the association with disease may be explained by the biologic properties of IL-1beta, which is an important proinflammatory cytokine and a powerful inhibitor of gastric acid secretion.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-IL1 beta/IL1B Antibody Picoband® catalog # PB9606. Tested in ELISA applications. This antibody reacts with Rat.
Function	Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as e
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of rat IL-1 beta, different from the related human sequence by five amino acids, and from the related mouse sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	35 kDa
Reactivity	Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Interleukin-1 beta;IL-1 beta;Il1b;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q63264
Gene Id	24494
Gene Name	Il1b
Sequence	Contains 1 IGFBP N-terminal domain.
Subcellular Location	Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA
Description	ELISA, 0.1-0.5ug/ml,

Reference	1. Baek, S. H.; Ohgi, K. A.; Rose, D. W.; Koo, E. H.; Glass, C. K.; Rosenfeld, M. G. : Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappa-B and beta-amyloid precursor protein. Cell 110: 55-67, 2002. 2. Chen, C.-N.; Li, Y.-S. J.; Yeh, Y.-T.; Lee, P.-L.; Usami, S.; Chien, S.; Chiu, J.-J. : Synergistic roles of platelet-derived growth factor-BB and interleukin-1-beta in phenotypic modulation of human aortic smooth muscle cells. Proc. Nat. Acad. Sci. 103: 2665-2670, 2006. 3. Takahashi, J. L.; Giuliani, F.; Power, C.; Imai, Y.; Yong, V. W. : Interleukin-1-beta promotes oligodendrocyte death through glutamate excitotoxicity. Ann. Neurol. 53: 588-595, 2003. 4. Voronov, E.; Shouval, D. S.; Krelin, Y.; Cagnano, E.; Benharroch, D.; Iwakura, Y.; Dinarello, C. A.; Apte, R. N. : IL-1 is required for tumor invasiveness and angiogenesis. Proc. Nat. Acad. Sci. 100: 2645-2650, 2003.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000502-1	PB9606	100 ug	-	$370		Add to Cart
BHA21000502-2	PB9606-10ug	10 ug	Sample	$99		Add to Cart
BHA21000502-3	PB9606-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000502-4	PB9606-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000502-5	PB9606-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000502-6	PB9606-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000502-7	PB9606-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000502-8	PB9606-FITC	100 ug	FITC	$570		Add to Cart
BHA21000502-9	PB9606-HRP	100 ug	HRP	$570		Add to Cart
BHA21000502-10	PB9606-APC	100 ug	APC	$670		Add to Cart
BHA21000502-11	PB9606-PE	100 ug	PE	$670		Add to Cart
BHA21000502-12	PB9606-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000502-13	PB9606-carrier-free	100 ug	carrier-free	$370		Add to Cart

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