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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IKK beta/IKBKB Antibody Picoband®

SKU : BHA21007253

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Mfr.No.	PA2036-1, PA2036-1-10ug, PA2036-1-Biotin, PA2036-1-Cy3, PA2036-1-Dylight488, PA2036-1-Dylight550, PA2036-1-Dylight594, PA2036-1-FITC, PA2036-1-HRP, PA2036-1-APC, PA2036-1-PE, PA2036-1-iFluor647, PA2036-1-carrier-free
Alternative Names	Inhibitor of nuclear factor kappa-B kinase subunit beta
Background	IKBKB (Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Kinase of, Beta), also known as IKKB or NFKBIKB , is a protein that in humans is encoded by the IKBKB gene. Shindo et al. (1998) mapped the IKBKB gene to chromosome 8p12-p11 by FISH. Mercurio et al. (1997) found that mutations in IKK2 had a more pronounced effect upon NFKB activation than did comparable mutations in IKK1. Yin et al. (1998) tested the activity of various antiinflammatory agents on the IKK complex. They demonstrated that aspirin and sodium salicylate specifically inhibit IKK-beta activity in vitro and in vivo by binding to IKK-beta to reduce ATP binding.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-IKK beta/IKBKB Antibody catalog # PA2036-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK c
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human IKK beta, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	87 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Inhibitor of nuclear factor kappa-B kinase subunit beta;I-kappa-B-kinase beta;IKK-B;IKK-beta;IkBKB;2.7.11.10;I-kappa-B kinase 2;IKK2;Nuclear factor NF-kappa-B inhibitor kinase beta;NFKBIKB;IKBKB;IKKB;
Tissue Specificity	Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O14920
Gene Name	IKBKB
Sequence	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Subcellular Location	Cytoplasm. Nucleus. Membrane raft. Colocalized with DPP4 in membrane rafts.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J., Young, D. B., Barbosa, M., Mann, M., Manning, A., Rao, A. IKK-1 and IKK-2: cytokine-activated I-kappa-B kinases essential for NF-kappa-B activation. Science 278: 860-866, 1997. <br /><br />2. Ozes, O. N., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M., Donner, D. B. NF-kappa-B activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401: 82-85, 1999.<br /><br />3. Yin, M.-J., Yamamoto, Y., Gaynor, R. B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I-kappa-B kinase-beta. Nature 396: 77-80, 1998.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007253-1	PA2036-1	-	100 ug	$370		Add to Cart
BHA21007253-2	PA2036-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21007253-3	PA2036-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007253-4	PA2036-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007253-5	PA2036-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007253-6	PA2036-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007253-7	PA2036-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007253-8	PA2036-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21007253-9	PA2036-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21007253-10	PA2036-1-APC	APC	100 ug	$670		Add to Cart
BHA21007253-11	PA2036-1-PE	PE	100 ug	$670		Add to Cart
BHA21007253-12	PA2036-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007253-13	PA2036-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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