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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IKB alpha/NFKBIA Antibody Picoband®

SKU : BHA21000215

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Mfr.No.	PB9291, PB9291-10ug, PB9291-Biotin, PB9291-Cy3, PB9291-Dylight488, PB9291-Dylight550, PB9291-Dylight594, PB9291-FITC, PB9291-HRP, PB9291-APC, PB9291-PE, PB9291-iFluor647, PB9291-carrier-free
Alternative Names	NF-kappa-B inhibitor alpha
Background	NFKBIA, also called IKBA or MAD-3, is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. It is mapped to 14q13.2. NFKBIA inhibits NF-κB by masking the nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. It moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. The effect of the nonpathogenic bacteria is specific to the SCF complex substrates CTNNB1 and NFKBIA. This may help to explain the beneficial effects of treatment of inflammatory bowel disease with nonpathogenic probiotic enteric organisms. In addition, NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-IKB alpha/NFKBIA Antibody Picoband® catalog # PB9291. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiq
Host	Rabbit
Immunogen Region	E.coli-derived human IKB alpha recombinant protein (Position: Q3-Q112). Human IKB alpha shares 87% and 86% amino acid (aa) sequence identity with mouse and rat IKB alpha, respectively.
Isotype	Rabbit IgG
Molecular Weight	39 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	NF-kappa-B inhibitor alpha;I-kappa-B-alpha;IkB-alpha;IkappaBalpha;Major histocompatibility complex enhancer-binding protein MAD3;NFKBIA;IKBA, MAD3, NFKBI;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P25963
Gene Id	4792
Gene Name	NFKBIA
Sequence	Belongs to the NF-kappa-B inhibitor family.
Subcellular Location	Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat

Reference	1. Jacobs MD, Harrison SC (1998). "Structure of an IkappaBalpha/NF-kappaB complex". Cell 95 (6): 74958. 2. Neish, A. S.., Gewirtz, A. T., Zeng, H., Young, A. N., Hobert, M. E., Karmali, V., Rao, A. S., Madara, J. L. Prokaryotic regulation of epithelial responses by inhibition of I-kappa-B-alpha ubiquitination. Science 289: 1560-1563, 2000. 3. Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S (1995). "Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation". Genes Dev.9 (22): 272335.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000215-1	PB9291	100 ug	-	$370		Add to Cart
BHA21000215-2	PB9291-10ug	10 ug	Sample	$99		Add to Cart
BHA21000215-3	PB9291-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000215-4	PB9291-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000215-5	PB9291-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000215-6	PB9291-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000215-7	PB9291-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000215-8	PB9291-FITC	100 ug	FITC	$570		Add to Cart
BHA21000215-9	PB9291-HRP	100 ug	HRP	$570		Add to Cart
BHA21000215-10	PB9291-APC	100 ug	APC	$670		Add to Cart
BHA21000215-11	PB9291-PE	100 ug	PE	$670		Add to Cart
BHA21000215-12	PB9291-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000215-13	PB9291-carrier-free	100 ug	carrier-free	$370		Add to Cart

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